Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration

Overview

Journal Front Chem

Specialty Chemistry

Date 2017 Nov 23

PMID 29164105

Citations 60

Authors

Yun Qian

Qixin Han

Wei Chen

Jialin Song

Xiaotian Zhao

Yuanming Ouyang

Weien Yuan

Cunyi Fan

Affiliations

Soon will be listed here.

Abstract

Stem cell treatment and platelet-rich plasma (PRP) therapy are two significant issues in regenerative medicine. Stem cells such as bone marrow mesenchymal stem cells, adipose-derived stem cells and periodontal ligament stem cells can be successfully applied in the field of tissue regeneration. PRP, a natural product isolated from whole blood, can secrete multiple growth factors (GFs) for regulating physiological activities. These GFs can stimulate proliferation and differentiation of different stem cells in injury models. Therefore, combination of both agents receives wide expectations in regenerative medicine, especially in bone, cartilage and tendon repair. In this review, we thoroughly discussed the interaction and underlying mechanisms of PRP derived GFs with stem cells, and assessed their functions in cell differentiation for musculoskeletal regeneration.

Citing Articles

Transcriptome Analysis of Platelet-Rich Plasma-Treated Osteoarthritic Chondrocyte.

Suh D, Yeo W, Cheong K, Heo J, Kim D, Lee S Biomed Res Int. 2024; 2024:7680736.

PMID: 39610694 PMC: 11604281. DOI: 10.1155/2024/7680736.

Chemical preconditioning escalates chondrogenic activity in explant cultured human dental pulp stem cell study model for future temporomandibular joint regeneration.

Shetty L, Waknis P, Kharat A, Bhonde R, Londhe U, Rudagi B Natl J Maxillofac Surg. 2024; 15(2):214-219.

PMID: 39234119 PMC: 11371304. DOI: 10.4103/njms.njms_207_23.

Decoding the Decade: Exploring the Efficacy of Platelet-Rich Plasma (PRP) in Complex Wound Management - A Comprehensive Study.

Shrivastava S, Patel S, Pundkar A, Jaiswal A, Shrivastava P Indian J Orthop. 2024; 58(8):1043-1052.

PMID: 39087047 PMC: 11286899. DOI: 10.1007/s43465-024-01212-5.

Alkali-extracted proteins from the tooth dentin matrix as a mixture of bioactive molecules for cartilage repair and regeneration.

Wang S, Mao S, Huang G, Jia P, Dong Y, Zheng J Regen Ther. 2024; 26:407-414.

PMID: 39070122 PMC: 11282981. DOI: 10.1016/j.reth.2024.06.015.

Microenvironmental interference with intra-articular stem cell regeneration influences the onset and progression of arthritis.

Shao Z, Wang B, Gao H, Zhang S Front Genet. 2024; 15:1380696.

PMID: 38841721 PMC: 11150611. DOI: 10.3389/fgene.2024.1380696.

References

Kreuz P, Kruger J, Metzlaff S, Freymann U, Endres M, Pruss A . Platelet-Rich Plasma Preparation Types Show Impact on Chondrogenic Differentiation, Migration, and Proliferation of Human Subchondral Mesenchymal Progenitor Cells. Arthroscopy. 2015; 31(10):1951-61. DOI: 10.1016/j.arthro.2015.03.033. View

Xiong J, Menicanin D, Zilm P, Marino V, Bartold P, Gronthos S . Investigation of the Cell Surface Proteome of Human Periodontal Ligament Stem Cells. Stem Cells Int. 2016; 2016:1947157. PMC: 4989088. DOI: 10.1155/2016/1947157. View

Kabiri A, Esfandiari E, Esmaeili A, Hashemibeni B, Pourazar A, Mardani M . Platelet-rich plasma application in chondrogenesis. Adv Biomed Res. 2014; 3:138. PMC: 4139981. DOI: 10.4103/2277-9175.135156. View

Majewski M, Ochsner P, Liu F, Fluckiger R, Evans C . Accelerated healing of the rat Achilles tendon in response to autologous conditioned serum. Am J Sports Med. 2009; 37(11):2117-25. DOI: 10.1177/0363546509348047. View

Hee C, Dines J, Dines D, Roden C, Wisner-Lynch L, Turner A . Augmentation of a rotator cuff suture repair using rhPDGF-BB and a type I bovine collagen matrix in an ovine model. Am J Sports Med. 2011; 39(8):1630-9. DOI: 10.1177/0363546511404942. View

Tobita M, Uysal C, Guo X, Hyakusoku H, Mizuno H . Periodontal tissue regeneration by combined implantation of adipose tissue-derived stem cells and platelet-rich plasma in a canine model. Cytotherapy. 2013; 15(12):1517-26. DOI: 10.1016/j.jcyt.2013.05.007. View

Jiritano F, Serraino G, Cristodoro L, Renzulli A . Ventricular assist device abdominal driveline infection: treatment with platelet-rich plasma. J Thorac Cardiovasc Surg. 2013; 145(6):e69-70. DOI: 10.1016/j.jtcvs.2013.02.072. View

Cheng M, Liu C, Chen T, Lee O . Optimization of culture conditions for stem cells derived from human anterior cruciate ligament and bone marrow. Cell Transplant. 2013; 23(7):791-803. DOI: 10.3727/096368912X666430. View

Kawaguchi H, Oka H, Jingushi S, Izumi T, Fukunaga M, Sato K . A local application of recombinant human fibroblast growth factor 2 for tibial shaft fractures: A randomized, placebo-controlled trial. J Bone Miner Res. 2010; 25(12):2735-43. DOI: 10.1002/jbmr.146. View

10.

Isaac C, Gharaibeh B, Witt M, Wright V, Huard J . Biologic approaches to enhance rotator cuff healing after injury. J Shoulder Elbow Surg. 2012; 21(2):181-90. DOI: 10.1016/j.jse.2011.10.004. View

11.

Busilacchi A, Gigante A, Mattioli-Belmonte M, Manzotti S, Muzzarelli R . Chitosan stabilizes platelet growth factors and modulates stem cell differentiation toward tissue regeneration. Carbohydr Polym. 2013; 98(1):665-76. DOI: 10.1016/j.carbpol.2013.06.044. View

12.

Akhundov K, Pietramaggiori G, Waselle L, Darwiche S, Guerid S, Scaletta C . Development of a cost-effective method for platelet-rich plasma (PRP) preparation for topical wound healing. Ann Burns Fire Disasters. 2013; 25(4):207-13. PMC: 3664531. View

13.

Chamberlain C, Leiferman E, Frisch K, Wang S, Yang X, van Rooijen N . The influence of macrophage depletion on ligament healing. Connect Tissue Res. 2010; 52(3):203-11. PMC: 3110150. DOI: 10.3109/03008207.2010.511355. View

14.

Martinez C, Gonzalez S, Palma V, Smith P . Platelet-Poor and Platelet-Rich Plasma Stimulate Bone Lineage Differentiation in Periodontal Ligament Stem Cells. J Periodontol. 2015; 87(2):e18-26. DOI: 10.1902/jop.2015.150360. View

15.

Daif E . Effect of autologous platelet-rich plasma on bone regeneration in mandibular fractures. Dent Traumatol. 2012; 29(5):399-403. DOI: 10.1111/edt.12021. View

16.

Clendenen T, Arslan A, Lokshin A, Idahl A, Hallmans G, Koenig K . Temporal reliability of cytokines and growth factors in EDTA plasma. BMC Res Notes. 2010; 3:302. PMC: 2997094. DOI: 10.1186/1756-0500-3-302. View

17.

Rubio-Azpeitia E, Sanchez P, Delgado D, Andia I . Adult Cells Combined With Platelet-Rich Plasma for Tendon Healing: Cell Source Options. Orthop J Sports Med. 2017; 5(2):2325967117690846. PMC: 5347436. DOI: 10.1177/2325967117690846. View

18.

Askarinam A, James A, Zara J, Goyal R, Corselli M, Pan A . Human perivascular stem cells show enhanced osteogenesis and vasculogenesis with Nel-like molecule I protein. Tissue Eng Part A. 2013; 19(11-12):1386-97. PMC: 3638559. DOI: 10.1089/ten.TEA.2012.0367. View

19.

Lin B, Whu S, Chen C, Hsu F, Chen J, Liu H . Bone marrow mesenchymal stem cells, platelet-rich plasma and nanohydroxyapatite-type I collagen beads were integral parts of biomimetic bone substitutes for bone regeneration. J Tissue Eng Regen Med. 2012; 7(11):841-54. DOI: 10.1002/term.1472. View

20.

Huber S, Cunha Junior J, Montalvao S, da Silva L, Urban Paffaro A, da Silva F . In vitro study of the role of thrombin in platelet rich plasma (PRP) preparation: utility for gel formation and impact in growth factors release. J Stem Cells Regen Med. 2016; 12(1):2-9. PMC: 4929890. View