Early Prenatal Vitamin D Concentrations and Social-emotional Development in Infants

Overview

Journal J Matern Fetal Neonatal Med

Publisher Informa Healthcare

Specialty Gynecology & Obstetrics

Date 2017 Nov 22

PMID 29157031

Citations 17

Authors

Devika Chawla

Bernard Fuemmeler

Sara E Benjamin-Neelon

Cathrine Hoyo

Susan Murphy

Julie L Daniels

Affiliations

Soon will be listed here.

Abstract

Background: Many pregnant women in the United States have suboptimal vitamin D, but the impact on infant development is unclear. Moreover, no pregnancy-specific vitamin D recommendations have been widely accepted.

Aims: Given the ubiquitous expression of vitamin D receptors in the brain, we investigated the association between early prenatal plasma 25-hydroxyvitamin D (25(OH)D) concentrations and children's social and emotional development in the Newborn Epigenetic Study, a prospective study of pregnancies from 2009 to 2011 in Durham, North Carolina.

Methods: We measured 25(OH)D concentrations in first or second trimester plasma samples and categorized 25(OH)D concentrations into quartiles. Covariates were derived from maternal questionnaires. Mothers completed the Infant Toddler Social-Emotional Development Assessment when children were 12-24 months of age. We used multivariable linear regression to evaluate associations between 25(OH)D and specific behavior scores, adjusted for season of blood draw, maternal age, education, parity, smoking, marital status, prepregnancy BMI, and infant gender. We investigated effect-measure modification by race/ethnicity.

Results: Of the 218 mother-infant pairs with complete data, Black mothers had much lower 25(OH)D concentrations as compared to White and Hispanic mothers. After adjustment, lower prenatal 25(OH)D was associated with slightly higher (less favorable) Internalizing scores among White children, but lower (more favorable) Internalizing scores among Black and Hispanic children. Lower prenatal 25(OH)D also appears to be associated with higher (less favorable) dysregulation scores, though only among White and Hispanic children.

Conclusions: Though imprecise, preliminary results warrant further investigation regarding a role for prenatal vitamin D on children's early social and emotional development.

Citing Articles

Preconception and prenatal vitamin D associations with positive behavioral health in Black children.

Hipwell A, Keenan K, Tung I, Quick A, Simhan H, Bodnar L Psychol Med. 2024; :1-12.

PMID: 39439316 PMC: 11579652. DOI: 10.1017/S0033291724002472.

Vitamin D levels of pregnant immigrant women and developmental disorders of language, learning and coordination in offspring.

Arrhenius B, Surcel H, Hinkka Yli-Salomaki S, Brown A, Cheslack-Postava K, Sourander A PLoS One. 2024; 19(2):e0299808.

PMID: 38422005 PMC: 10903893. DOI: 10.1371/journal.pone.0299808.

Diminished social motivation in early psychosis is associated with polygenic liability for low vitamin D.

Hatzimanolis A, Tosato S, Ruggeri M, Cristofalo D, Mantonakis L, Xenaki L Transl Psychiatry. 2024; 14(1):36.

PMID: 38238289 PMC: 10796745. DOI: 10.1038/s41398-024-02750-0.

Vitamin D and Child Neurodevelopment-A Post Hoc Analysis.

Rodgers M, Mead M, McWhorter C, Ebeling M, Shary J, Newton D Nutrients. 2023; 15(19).

PMID: 37836534 PMC: 10574578. DOI: 10.3390/nu15194250.

"You are my sunshine, my only sunshine": maternal vitamin D status and supplementation in pregnancy and their effect on neonatal and childhood outcomes.

Vasdeki D, Tsamos G, Koufakis T, Goulis D, Asimakopoulos B, Michou V Hormones (Athens). 2023; 22(4):547-562.

PMID: 37698832 DOI: 10.1007/s42000-023-00486-y.

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