FcGBP Was Upregulated by HPV Infection and Correlated to Longer Survival Time of HNSCC Patients

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Nov 22

PMID 29156811

Citations 17

Authors

Yating Wang

Yan Liu

Huiqiao Liu

Qingan Zhang

Hongyan Song

Jianliang Tang

Jiangtao Fu

Xiaofei Wang

Affiliations

Soon will be listed here.

Abstract

FcGBP was normally found in intestinal and colonic epithelia, gallbladder, cystic duct, bronchus, submandibular gland, cervix uteri and in fluids secreted by these cells in humans, and was down-regulated during colon carcinogenesis. We found FcGBP gene expression was decreased in HNSCC tissues compared to surgical safety border tissues while TGF-β expression level increased in HNSCC tissues, and higher FcGBP expression level was correlated to longer OS time of HNSCC patients. FcGBP expression level was higher in HPV-positive HNSCC tissues compared to HPV-negative HNSCC tissues, while TGF-β expression level was lower in HPV-positive HNSCC tissues. Gene expression level of FcGBP and TGF-β was negatively correlated in HNSCC tissues. FcGBP expression level increased after HPV E6 overexpression in HPV-negative HNSCC cells, and TGF-β could inhibit the up-regulation of FcGBP after HPV E6 or FcGBP overexpression in HPV-negative HNSCC cells. The migration capability was inhibited after FcGBP overexpression, and TGF-β could counteract the inhibition of migration caused by FcGBP overexpression. FcGBP gene expression level was correlated to the expression levels of EMT markers. In conclusion, FCGBP expression was upregulated by HPV infection while inhibited by TGF-β, and was correlated to the prognosis of HNSCC patients.

Citing Articles

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FCGBP functions as a tumor suppressor gene in head and neck squamous cell carcinoma.

Zeng L, Zeng J, He J, Li Y, Li C, Lin Z Discov Oncol. 2024; 15(1):704.

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Role of the mucin-like glycoprotein FCGBP in mucosal immunity and cancer.

Liu Q, Niu X, Li Y, Zhang J, Zhu S, Yang Q Front Immunol. 2022; 13:863317.

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References

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M . Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2014; 136(5):E359-86. DOI: 10.1002/ijc.29210. View

Schwartz J . Fcgbp - A Potential Viral Trap in RV144. Open AIDS J. 2014; 8:21-4. PMC: 4166788. DOI: 10.2174/1874613601408010021. View

Selbach M, Mann M . Protein interaction screening by quantitative immunoprecipitation combined with knockdown (QUICK). Nat Methods. 2006; 3(12):981-3. DOI: 10.1038/nmeth972. View

Kim M, Lee S, Yang S, Song K, Lee I . Differential expression in histologically normal crypts of ulcerative colitis suggests primary crypt disorder. Oncol Rep. 2006; 16(4):663-70. View

Johansson M, Thomsson K, Hansson G . Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. J Proteome Res. 2009; 8(7):3549-57. DOI: 10.1021/pr9002504. View

Firmino N, Martinez V, Rowbotham D, Enfield K, Bennewith K, Lam W . HPV status is associated with altered PIWI-interacting RNA expression pattern in head and neck cancer. Oral Oncol. 2016; 55:43-48. PMC: 4808439. DOI: 10.1016/j.oraloncology.2016.01.012. View

Steuer C, El-Deiry M, Parks J, Higgins K, Saba N . An update on larynx cancer. CA Cancer J Clin. 2016; 67(1):31-50. DOI: 10.3322/caac.21386. View

Griffith O, Melck A, Jones S, Wiseman S . Meta-analysis and meta-review of thyroid cancer gene expression profiling studies identifies important diagnostic biomarkers. J Clin Oncol. 2006; 24(31):5043-51. DOI: 10.1200/JCO.2006.06.7330. View

Lassen P, Eriksen J, Hamilton-Dutoit S, Tramm T, Alsner J, Overgaard J . Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck. J Clin Oncol. 2009; 27(12):1992-8. DOI: 10.1200/JCO.2008.20.2853. View

10.

Risques R, Lai L, Himmetoglu C, Ebaee A, Li L, Feng Z . Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation. Cancer Res. 2011; 71(5):1669-79. PMC: 3077943. DOI: 10.1158/0008-5472.CAN-10-1966. View

11.

Byers T, Wender R, Jemal A, Baskies A, Ward E, Brawley O . The American Cancer Society challenge goal to reduce US cancer mortality by 50% between 1990 and 2015: Results and reflections. CA Cancer J Clin. 2016; 66(5):359-69. DOI: 10.3322/caac.21348. View

12.

Kowli S, Velidandla R, Creek K, Pirisi L . TGF-β regulation of gene expression at early and late stages of HPV16-mediated transformation of human keratinocytes. Virology. 2013; 447(1-2):63-73. PMC: 3895483. DOI: 10.1016/j.virol.2013.08.034. View

13.

Yasui Y, Tanaka T . Protein expression analysis of inflammation-related colon carcinogenesis. J Carcinog. 2009; 8:10. PMC: 2699605. DOI: 10.4103/1477-3163.51851. View

14.

Polz-Dacewicz M, Strycharz-Dudziak M, Dworzanski J, Stec A, Kocot J . Salivary and serum IL-10, TNF-α, TGF-β, VEGF levels in oropharyngeal squamous cell carcinoma and correlation with HPV and EBV infections. Infect Agent Cancer. 2016; 11:45. PMC: 4992298. DOI: 10.1186/s13027-016-0093-6. View

15.

Marur S, DSouza G, Westra W, Forastiere A . HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol. 2010; 11(8):781-9. PMC: 5242182. DOI: 10.1016/S1470-2045(10)70017-6. View

16.

Spisak S, Kalmar A, Galamb O, Wichmann B, Sipos F, Peterfia B . Genome-wide screening of genes regulated by DNA methylation in colon cancer development. PLoS One. 2012; 7(10):e46215. PMC: 3462205. DOI: 10.1371/journal.pone.0046215. View

17.

Wang Y, Chen C, Wang X, Jin F, Liu Y, Liu H . Lower DSC1 expression is related to the poor differentiation and prognosis of head and neck squamous cell carcinoma (HNSCC). J Cancer Res Clin Oncol. 2016; 142(12):2461-2468. DOI: 10.1007/s00432-016-2233-1. View

18.

Harada N, Iijima S, Kobayashi K, Yoshida T, Brown W, Hibi T . Human IgGFc binding protein (FcgammaBP) in colonic epithelial cells exhibits mucin-like structure. J Biol Chem. 1997; 272(24):15232-41. DOI: 10.1074/jbc.272.24.15232. View

19.

Bendas G, Borsig L . Cancer cell adhesion and metastasis: selectins, integrins, and the inhibitory potential of heparins. Int J Cell Biol. 2012; 2012:676731. PMC: 3296185. DOI: 10.1155/2012/676731. View

20.

Albert T, Laubinger W, Muller S, Hanisch F, Kalinski T, Meyer F . Human intestinal TFF3 forms disulfide-linked heteromers with the mucus-associated FCGBP protein and is released by hydrogen sulfide. J Proteome Res. 2010; 9(6):3108-17. DOI: 10.1021/pr100020c. View