Demonstration of Zoster Virus Antibodies in Cerebrospinal Fluid Cells

Overview

Journal J Neurol

Specialty Neurology

Date 1989 Jan 1

PMID 2915223

Citations 5

Authors

W Beuche

R S Thomas

K FELGENHAUER

Affiliations

Soon will be listed here.

Abstract

A method is presented that allows the immunocytochemical detection of varicella zoster virus antigen-binding cerebrospinal fluid cells in zoster ganglionitis. Antigen-binding cells were found only in patients suffering from this disease. The technique is sensitive, specific, inexpensive and relatively fast, and is potentially applicable to other inflammatory central nervous system diseases with immunoglobulin-containing cells (ICC) in CSF. The detection of antigen-binding CSF cells may represent a very early diagnostic test comparable with the early IgM antibodies of the systemic immune response.

Citing Articles

Demonstration of herpes simplex virus DNA in CSF cells by in situ hybridization for early diagnosis of herpes encephalitis.

Bamborschke S, Porr A, Huber M, Heiss W J Neurol. 1990; 237(2):73-6.

PMID: 2162383 DOI: 10.1007/BF00314664.

The proliferation rate of T and B lymphocytes in cerebrospinal fluid.

Thomas R, Beuche W, FELGENHAUER K J Neurol. 1991; 238(1):27-30.

PMID: 2030368 DOI: 10.1007/BF00319706.

Specific antigen binding by activated cerebrospinal fluid B lymphocytes in acute neuroborreliosis.

Beuche W, Siever A, FELGENHAUER K J Neurol. 1992; 239(6):322-6.

PMID: 1512607 DOI: 10.1007/BF00867588.

The diagnostic significance of antibody specificity indices in multiple sclerosis and herpes virus induced diseases of the nervous system.

FELGENHAUER K, Reiber H Clin Investig. 1992; 70(1):28-37.

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Detection of varicella-zoster virus DNA by polymerase chain reaction in cerebrospinal fluid of patients with herpes zoster meningitis.

Shoji H, Honda Y, Murai I, Sato Y, Oizumi K, Hondo R J Neurol. 1992; 239(2):69-70.

PMID: 1313077 DOI: 10.1007/BF00862974.

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