Cortactin in Cancer Cell Migration and Invasion

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Nov 21

PMID 29152154

Citations 37

Authors

Miao Yin

Wenqing Ma

Liguo An

Affiliations

Soon will be listed here.

Abstract

Cortactin, a substrate of sarcoma (Src) kinases, is an actin-binding protein that is involved in cytoskeletal regulation, and is frequently overexpressed in cancer cells. Binding to the actin related protein 2/3 (Arp2/3) complex stimulates cortactin activity, which promotes F-actin nucleation and assembly. Cortactin promotes cancer cell migration and invasion, and plays a pivotal role in invadopodia formation and extra cellular matrix degradation. Overexpression of cortactin, by amplification of the chromosomal band 11q13, increases tumor aggressiveness. In this review, we report on the current knowledge and potential mechanisms of action of cortactin as a critical mediator of cancer cell migration and invasion.

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