MicroRNA Tissue Atlas of the Malaria Mosquito

Overview

Journal G3 (Bethesda)

Publisher Oxford University Press

Specialties Genetics
Molecular Biology

Date 2017 Nov 18

PMID 29146584

Citations 16

Authors

Lena Lampe

Elena A Levashina

Affiliations

Soon will be listed here.

Abstract

mosquitoes transmit the human malaria parasite , which causes the majority of fatal malaria cases worldwide. The hematophagous lifestyle defines mosquito reproductive biology and is exploited by for its own sexual reproduction and transmission. The two main phases of the mosquito reproductive cycle, previtellogenic (PV) and postblood meal (PBM), shape its capacity to transmit malaria. Transition between these phases is tightly coordinated to ensure homeostasis between mosquito tissues and successful reproduction. One layer of control is provided by microRNAs (miRNAs), well-known regulators of blood meal digestion and egg development in mosquitoes. Here, we report a global overview of tissue-specific miRNAs (miRNA) expression during the PV and PBM phases and identify miRNAs regulated during PV to PBM transition. The observed coordinated changes in the expression levels of a set of miRNAs in the energy-storing tissues suggest a role in the regulation of blood meal-induced metabolic changes.

Citing Articles

MicroRNA-989 targets 5-hydroxytryptamine receptor1 to regulate ovarian development and eggs production in Culex pipiens pallens.

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microRNA Expression Dynamics in Biting Midges Following Blood-Feeding.

Mills M, Rozo-Lopez P, Bryant W, Drolet B Insects. 2023; 14(7).

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miR-275/305 cluster is essential for maintaining energy metabolic homeostasis by the insulin signaling pathway in Bactrocera dorsalis.

Xie J, Chen H, Zheng W, Cai Z, Li X, Zhang H PLoS Genet. 2022; 18(10):e1010418.

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The Tsetse Metabolic Gambit: Living on Blood by Relying on Symbionts Demands Synchronization.

Lee M, Medina Munoz M, Rio R Front Microbiol. 2022; 13:905826.

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Vector competence of Aedes aegypti and screening for differentially expressed microRNAs exposed to Zika virus.

Zhu C, Jiang Y, Zhang Q, Gao J, Li C, Li C Parasit Vectors. 2021; 14(1):504.

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References

Hagedorn H, OConnor J, Fuchs M, Sage B, Schlaeger D, Bohm M . The ovary as a source of alpha-ecdysone in an adult mosquito. Proc Natl Acad Sci U S A. 1975; 72(8):3255-9. PMC: 432961. DOI: 10.1073/pnas.72.8.3255. View

Nishitani S, Matsumura T, Fujitani S, Sonaka I, Miura Y, Yagasaki K . Leucine promotes glucose uptake in skeletal muscles of rats. Biochem Biophys Res Commun. 2002; 299(5):693-6. DOI: 10.1016/s0006-291x(02)02717-1. View

Ijichi C, Matsumura T, Tsuji T, Eto Y . Branched-chain amino acids promote albumin synthesis in rat primary hepatocytes through the mTOR signal transduction system. Biochem Biophys Res Commun. 2003; 303(1):59-64. DOI: 10.1016/s0006-291x(03)00295-x. View

Hansen I, Attardo G, Park J, Peng Q, Raikhel A . Target of rapamycin-mediated amino acid signaling in mosquito anautogeny. Proc Natl Acad Sci U S A. 2004; 101(29):10626-31. PMC: 489984. DOI: 10.1073/pnas.0403460101. View

Brown M, Cao C . Distribution of ovary ecdysteroidogenic hormone I in the nervous system and gut of mosquitoes. J Insect Sci. 2004; 1:3. PMC: 355887. DOI: 10.1093/jis/1.1.3. View

Hansen I, Attardo G, Roy S, Raikhel A . Target of rapamycin-dependent activation of S6 kinase is a central step in the transduction of nutritional signals during egg development in a mosquito. J Biol Chem. 2005; 280(21):20565-72. DOI: 10.1074/jbc.M500712200. View

Attardo G, Hansen I, Raikhel A . Nutritional regulation of vitellogenesis in mosquitoes: implications for anautogeny. Insect Biochem Mol Biol. 2005; 35(7):661-75. DOI: 10.1016/j.ibmb.2005.02.013. View

Park J, Attardo G, Hansen I, Raikhel A . GATA factor translation is the final downstream step in the amino acid/target-of-rapamycin-mediated vitellogenin gene expression in the anautogenous mosquito Aedes aegypti. J Biol Chem. 2006; 281(16):11167-76. DOI: 10.1074/jbc.M601517200. View

Zhu J, Chen L, Sun G, Raikhel A . The competence factor beta Ftz-F1 potentiates ecdysone receptor activity via recruiting a p160/SRC coactivator. Mol Cell Biol. 2006; 26(24):9402-12. PMC: 1698532. DOI: 10.1128/MCB.01318-06. View

10.

Lu T, Qiu Y, Wang G, Kwon J, Rutzler M, Kwon H . Odor coding in the maxillary palp of the malaria vector mosquito Anopheles gambiae. Curr Biol. 2007; 17(18):1533-44. PMC: 3113458. DOI: 10.1016/j.cub.2007.07.062. View

11.

She P, Reid T, Bronson S, Vary T, Hajnal A, Lynch C . Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. Cell Metab. 2007; 6(3):181-94. PMC: 2693888. DOI: 10.1016/j.cmet.2007.08.003. View

12.

Winter F, Edaye S, Huttenhofer A, Brunel C . Anopheles gambiae miRNAs as actors of defence reaction against Plasmodium invasion. Nucleic Acids Res. 2007; 35(20):6953-62. PMC: 2175301. DOI: 10.1093/nar/gkm686. View

13.

Shiao S, Hansen I, Zhu J, Sieglaff D, Raikhel A . Juvenile hormone connects larval nutrition with target of rapamycin signaling in the mosquito Aedes aegypti. J Insect Physiol. 2007; 54(1):231-9. PMC: 2242809. DOI: 10.1016/j.jinsphys.2007.09.007. View

14.

Atella G, Bittencourt-Cunha P, Nunes R, Shahabuddin M, Silva-Neto M . The major insect lipoprotein is a lipid source to mosquito stages of malaria parasite. Acta Trop. 2008; 109(2):159-62. DOI: 10.1016/j.actatropica.2008.10.004. View

15.

Chen Q, Reimer R . Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro. Nutrition. 2008; 25(3):340-9. PMC: 3827015. DOI: 10.1016/j.nut.2008.08.012. View

16.

Carey A, Wang G, Su C, Zwiebel L, Carlson J . Odorant reception in the malaria mosquito Anopheles gambiae. Nature. 2010; 464(7285):66-71. PMC: 2833235. DOI: 10.1038/nature08834. View

17.

Chiang H, Schoenfeld L, Ruby J, Auyeung V, Spies N, Baek D . Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genes Dev. 2010; 24(10):992-1009. PMC: 2867214. DOI: 10.1101/gad.1884710. View

18.

Rono M, Whitten M, Oulad-Abdelghani M, Levashina E, Marois E . The major yolk protein vitellogenin interferes with the anti-plasmodium response in the malaria mosquito Anopheles gambiae. PLoS Biol. 2010; 8(7):e1000434. PMC: 2907290. DOI: 10.1371/journal.pbio.1000434. View

19.

Marco A, Hui J, Ronshaugen M, Griffiths-Jones S . Functional shifts in insect microRNA evolution. Genome Biol Evol. 2010; 2:686-96. PMC: 2956262. DOI: 10.1093/gbe/evq053. View

20.

Bryant B, Macdonald W, Raikhel A . microRNA miR-275 is indispensable for blood digestion and egg development in the mosquito Aedes aegypti. Proc Natl Acad Sci U S A. 2010; 107(52):22391-8. PMC: 3012520. DOI: 10.1073/pnas.1016230107. View