The Renal Pathology of Obesity

Overview

Journal Kidney Int Rep

Publisher Elsevier

Specialty Nephrology

Date 2017 Nov 17

PMID 29142961

Citations 80

Authors

Nobuo Tsuboi

Yusuke Okabayashi

Akira Shimizu

Takashi Yokoo

Affiliations

Soon will be listed here.

Abstract

Obesity causes various structural, hemodynamic, and metabolic alterations in the kidney. Most of these are likely to be compensatory responses to the systemic increase in metabolic demand that is seen with obesity. In some cases, however, renal injury becomes clinically apparent as a result of compensatory failure. Obesity-related glomerulopathy is the best known of such disease states. Factors that may sensitize obese individuals to renal compensatory failure and associated injury include the severity and number of obesity-associated conditions or complications, including components of metabolic syndrome, and the mismatch of body size to nephron mass, due to nephron reductions of congenital or acquired origin.

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