Transplantation of Renal Allografts From Organ Donors Reactive for HCV Antibodies to HCV-Negative Recipients: Safety and Clinical Outcome

Overview

Journal Kidney Int Rep

Publisher Elsevier

Specialty Nephrology

Date 2017 Nov 17

PMID 29142940

Citations 7

Authors

Knut Michael Nowak

Oliver Witzke

Georgios C Sotiropoulos

Tamas Benko

Melanie Fiedler

Jorg Timm

Andreas Kribben

Benjamin Wilde

Fuat Saner

Andreas Paul

Jurgen Treckmann

Affiliations

Soon will be listed here.

Abstract

Introduction: Because of the shortage of available organs for renal transplantation, strategies enabling the safe use of organs from donors with potential chronic infections such as hepatitis C are necessary. The aim of this study was to analyze the outcome of renal transplant donation from hepatitis C virus (HCV)-positive donors.

Methods: Between September 2002 and May 2007, 51 kidneys (34 donors) reactive for HCV antibodies were further evaluated. Six kidneys (5 donors) were transplanted to 6 recipients with known chronic HCV infection. The remaining 29 donors underwent extended virological testing. Nine donors were HCV RNA positive and thus not suitable for HCV-negative patients. Twenty donors (21 kidneys) did not have detectable HCV RNA copies and were transplanted into 21 HCV-negative recipients. Clinical outcomes focusing on safety, allograft function, and HCV infection in the recipient were collected.

Results: There were no HCV infections detected in recipients who were HCV negative before transplantation. The extended virological donor screening did not have an impact on median cold ischemia time. Five-year graft survival was 75%.

Discussion: Organs from anti-HCV-reactive, nonviremic donors can be transplanted safely to HCV-negative recipients.

Citing Articles

Use of Hepatitis C Virus Antibody-Positive Donors in Kidney Transplantation.

Ventura S, Figueiredo C, Sousa C, Almeida M, Martins L Cureus. 2024; 16(1):e51849.

PMID: 38327969 PMC: 10848599. DOI: 10.7759/cureus.51849.

Outcome of Kidney Transplants from Viremic and Non-Viremic Hepatitis C Virus Positive Donors into Negative Recipients: Results of the Spanish Registry.

Franco A, Moreso F, Sola-Porta E, Beneyto I, Esforzado N, Gonzalez-Roncero F J Clin Med. 2023; 12(5).

PMID: 36902560 PMC: 10002558. DOI: 10.3390/jcm12051773.

An Update on Usage of High-Risk Donors in Liver Transplantation.

Muhammad H, Zaffar D, Tehreem A, Ting P, Simsek C, Turan I J Clin Med. 2022; 11(1).

PMID: 35011956 PMC: 8746244. DOI: 10.3390/jcm11010215.

Transplant of a Kidney from a Hepatitis C Viremic Donor to a Naïve Recipient without Viral Transmission: A Case Report.

Rawashdeh B, Hulse J, Agarwal A Am J Case Rep. 2021; 22:e927532.

PMID: 33953151 PMC: 8112284. DOI: 10.12659/AJCR.927532.

Updated View on Kidney Transplant from HCV-Infected Donors and DAAs.

Fabrizi F, Cerutti R, Alfieri C, Messa P Pharmaceutics. 2021; 13(4).

PMID: 33917382 PMC: 8067384. DOI: 10.3390/pharmaceutics13040496.

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