Long Noncoding RNA H19 Interacts with Polypyrimidine Tract-binding Protein 1 to Reprogram Hepatic Lipid Homeostasis

Overview

Journal Hepatology

Specialty Gastroenterology

Date 2017 Nov 16

PMID 29140550

Citations 93

Authors

Chune Liu

Zhihong Yang

Jianguo Wu

Li Zhang

Sangmin Lee

Dong-Ju Shin

Melanie Tran

Li Wang

Affiliations

Soon will be listed here.

Abstract

Conclusion: Our study unveils an H19/PTBP1/sterol regulatory element-binding protein 1 feedforward amplifying signaling pathway to exacerbate the development of fatty liver. (Hepatology 2018;67:1768-1783).

Citing Articles

Defined Diets Link Iron and α-Linolenic Acid to Cyp1b1 Regulation of Neonatal Liver Development Through Srebp Forms and LncRNA H19.

Jefcoate C, Larsen M, Song Y, Maguire M, Sheibani N Int J Mol Sci. 2025; 26(5).

PMID: 40076634 PMC: 11901102. DOI: 10.3390/ijms26052011.

The circular RNA circbabo(5,6,7,8S) regulates lipid metabolism and neuronal integrity via TGF-β/ROS/JNK/SREBP signaling axis in Drosophila.

Sheng J, Zhang X, Liang W, Lyu J, Zhang B, Min J BMC Biol. 2025; 23(1):69.

PMID: 40038674 PMC: 11881384. DOI: 10.1186/s12915-025-02175-1.

Role of long noncoding RNAs in the regulation of epithelial‑mesenchymal transition in osteosarcoma (Review).

Li Z, Tian Y Oncol Rep. 2025; 53(3).

PMID: 39930817 PMC: 11783035. DOI: 10.3892/or.2025.8868.

Mechanistic role of long non-coding RNAs in the pathogenesis of metabolic dysfunction-associated steatotic liver disease and fibrosis.

Wade H, Pan K, Zhang B, Zheng W, Su Q eGastroenterology. 2025; 2(4):e100115.

PMID: 39872125 PMC: 11729351. DOI: 10.1136/egastro-2024-100115.

A novel human specific lncRNA MEK6-AS1 regulates adipogenesis and fatty acid biosynthesis by stabilizing MEK6 mRNA.

Li D, Chen Y, Zhu X, Yang Y, Li H, Zhao R J Biomed Sci. 2025; 32(1):6.

PMID: 39773638 PMC: 11708274. DOI: 10.1186/s12929-024-01098-3.

References

Taniguchi C, Emanuelli B, Kahn C . Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol. 2006; 7(2):85-96. DOI: 10.1038/nrm1837. View

Pacana T, Sanyal A . Vitamin E and nonalcoholic fatty liver disease. Curr Opin Clin Nutr Metab Care. 2012; 15(6):641-8. PMC: 4984672. DOI: 10.1097/MCO.0b013e328357f747. View

Wang L, Liu J, Saha P, Huang J, Chan L, Spiegelman B . The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metab. 2005; 2(4):227-38. DOI: 10.1016/j.cmet.2005.08.010. View

Guerrero R, Vega G, Grundy S, Browning J . Ethnic differences in hepatic steatosis: an insulin resistance paradox?. Hepatology. 2008; 49(3):791-801. PMC: 2675577. DOI: 10.1002/hep.22726. View

Lin N, Chang K, Li Z, Gates K, Rana Z, Dang J . An evolutionarily conserved long noncoding RNA TUNA controls pluripotency and neural lineage commitment. Mol Cell. 2014; 53(6):1005-19. PMC: 4010157. DOI: 10.1016/j.molcel.2014.01.021. View

Lee S, Zhang Y, Tsuchiya H, Smalling R, Jetten A, Wang L . Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism. Hepatology. 2014; 61(2):497-505. PMC: 4303514. DOI: 10.1002/hep.27437. View

Ferrarese R, Harsh 4th G, Yadav A, Bug E, Maticzka D, Reichardt W . Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression. J Clin Invest. 2014; 124(7):2861-76. PMC: 4071411. DOI: 10.1172/JCI68836. View

Zhao Y, Yang Z, Wu J, Wu R, Keshipeddy S, Wright D . High-mobility-group protein 2 regulated by microRNA-127 and small heterodimer partner modulates pluripotency of mouse embryonic stem cells and liver tumor initiating cells. Hepatol Commun. 2017; 1(8):816-830. PMC: 5678910. DOI: 10.1002/hep4.1086. View

Song Y, Liu C, Liu X, Trottier J, Beaudoin M, Zhang L . H19 promotes cholestatic liver fibrosis by preventing ZEB1-mediated inhibition of epithelial cell adhesion molecule. Hepatology. 2017; 66(4):1183-1196. PMC: 5605402. DOI: 10.1002/hep.29209. View

10.

Korenblat K, Fabbrini E, Mohammed B, Klein S . Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology. 2008; 134(5):1369-75. PMC: 2629391. DOI: 10.1053/j.gastro.2008.01.075. View

11.

Keppetipola N, Sharma S, Li Q, Black D . Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2. Crit Rev Biochem Mol Biol. 2012; 47(4):360-78. PMC: 3422667. DOI: 10.3109/10409238.2012.691456. View

12.

Bugianesi E, Leone N, Vanni E, Marchesini G, Brunello F, Carucci P . Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology. 2002; 123(1):134-40. DOI: 10.1053/gast.2002.34168. View

13.

Zhang L, Yang Z, Trottier J, Barbier O, Wang L . Long noncoding RNA MEG3 induces cholestatic liver injury by interaction with PTBP1 to facilitate shp mRNA decay. Hepatology. 2016; 65(2):604-615. PMC: 5258819. DOI: 10.1002/hep.28882. View

14.

Li P, Ruan X, Yang L, Kiesewetter K, Zhao Y, Luo H . A liver-enriched long non-coding RNA, lncLSTR, regulates systemic lipid metabolism in mice. Cell Metab. 2015; 21(3):455-67. PMC: 4350020. DOI: 10.1016/j.cmet.2015.02.004. View

15.

Jiao P, Feng B, Li Y, He Q, Xu H . Hepatic ERK activity plays a role in energy metabolism. Mol Cell Endocrinol. 2013; 375(1-2):157-66. PMC: 3733366. DOI: 10.1016/j.mce.2013.05.021. View

16.

Han J, Li E, Chen L, Zhang Y, Wei F, Liu J . The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. Nature. 2015; 524(7564):243-6. DOI: 10.1038/nature14557. View

17.

Xue Y, Ouyang K, Huang J, Zhou Y, Ouyang H, Li H . Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell. 2013; 152(1-2):82-96. PMC: 3552026. DOI: 10.1016/j.cell.2012.11.045. View

18.

Ramos A, Andersen R, Liu S, Nowakowski T, Hong S, Gertz C . The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells. Cell Stem Cell. 2015; 16(4):439-447. PMC: 4388801. DOI: 10.1016/j.stem.2015.02.007. View

19.

Zhang Y, Liu C, Barbier O, Smalling R, Tsuchiya H, Lee S . Bcl2 is a critical regulator of bile acid homeostasis by dictating Shp and lncRNA H19 function. Sci Rep. 2016; 6:20559. PMC: 4738356. DOI: 10.1038/srep20559. View

20.

Watanabe M, Houten S, Wang L, Moschetta A, Mangelsdorf D, Heyman R . Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest. 2004; 113(10):1408-18. PMC: 406532. DOI: 10.1172/JCI21025. View