Frequent Nonallelic Gene Conversion on the Human Lineage and Its Effect on the Divergence of Gene Duplicates

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2017 Nov 16

PMID 29138319

Citations 20

Authors

Arbel Harpak

Xun Lan

Ziyue Gao

Jonathan K Pritchard

Affiliations

Soon will be listed here.

Abstract

Gene conversion is the copying of a genetic sequence from a "donor" region to an "acceptor." In nonallelic gene conversion (NAGC), the donor and the acceptor are at distinct genetic loci. Despite the role NAGC plays in various genetic diseases and the concerted evolution of gene families, the parameters that govern NAGC are not well characterized. Here, we survey duplicate gene families and identify converted tracts in 46% of them. These conversions reflect a large GC bias of NAGC. We develop a sequence evolution model that leverages substantially more information in duplicate sequences than used by previous methods and use it to estimate the parameters that govern NAGC in humans: a mean converted tract length of 250 bp and a probability of [Formula: see text] per generation for a nucleotide to be converted (an order of magnitude higher than the point mutation rate). Despite this high baseline rate, we show that NAGC slows down as duplicate sequences diverge-until an eventual "escape" of the sequences from its influence. As a result, NAGC has a small average effect on the sequence divergence of duplicates. This work improves our understanding of the NAGC mechanism and the role that it plays in the evolution of gene duplicates.

Citing Articles

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Interlocus Gene Conversion, Natural Selection, and Paralog Homogenization.

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Increased mutation and gene conversion within human segmental duplications.

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