New Advances in Understanding the Host Immune Response to Pneumocystis

Overview

Journal Curr Opin Microbiol

Specialty Microbiology

Date 2017 Nov 15

PMID 29136537

Citations 16

Authors

J Claire Hoving

Jay K Kolls

Affiliations

Soon will be listed here.

Abstract

Pneumocystis jirovecii causes clinical pneumonia in immunocompromised hosts. Despite this, the inability to cultivate this organism in vitro has likely hindered the field in ascertaining the true impact of Pneumocystis in human infection. However the recent release of the genome as well as in advances in understanding host genetics, and other risk factors for infection and robust experimental models of disease have shed new light on the impact of this fungal pathogen as to better define populations at risk. This review will highlight these recent advances as well as highlight future needed areas of research.

Citing Articles

Pneumocystis Jirovecii Pneumonia in Two Immunosuppressed Non-HIV Infected Patients: A Clinical and Therapeutic Analysis.

Li W, Hua M, Guo J, Jia W Infect Drug Resist. 2025; 18():285-295.

PMID: 39835165 PMC: 11742741. DOI: 10.2147/IDR.S495188.

Protocol for the systematic review of the Pneumocystis jirovecii-associated pneumonia in non-HIV immunocompromised patients.

Orozco-Ugarriza M, Olivo-Martinez Y, Rodger-Cervantes Y PLoS One. 2024; 19(5):e0302055.

PMID: 38722952 PMC: 11081338. DOI: 10.1371/journal.pone.0302055.

CMV Infection and Lymphopenia: Warning Markers of Pneumonia in Kidney Transplant Recipients.

Eberl I, Binquet C, Guilloteau A, Legendre M, Dalle F, Piroth L Transpl Int. 2024; 37:12192.

PMID: 38328616 PMC: 10849047. DOI: 10.3389/ti.2024.12192.

Immune responses to human fungal pathogens and therapeutic prospects.

Lionakis M, Drummond R, Hohl T Nat Rev Immunol. 2023; 23(7):433-452.

PMID: 36600071 DOI: 10.1038/s41577-022-00826-w.

Exploring the Differences in Pneumocystis Pneumonia Infection Between HIV and Non-HIV Patients.

Nasr M, Mohammad A, Hor M, Baradeiya A, Qasim H Cureus. 2022; 14(8):e27727.

PMID: 36106266 PMC: 9441775. DOI: 10.7759/cureus.27727.

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