Roux-en-Y Gastric Bypass Reduces Plasma Cholesterol in Diet-induced Obese Mice by Affecting Trans-intestinal Cholesterol Excretion and Intestinal Cholesterol Absorption

Overview

Journal Int J Obes (Lond)

Specialty Endocrinology

Date 2017 Nov 15

PMID 29135972

Citations 6

Authors

C Blanchard

F Moreau

A Ayer

L Toque

D Garcon

L Arnaud

F Borel

A Aguesse

M Croyal

M Krempf

X Prieur

M Neunlist

B Cariou

C Le May

Affiliations

Soon will be listed here.

Abstract

Objective: Bariatric surgery appears as the most efficient therapeutic alternative in morbidly obese patients. In addition to its efficiency to decrease body weight, it also improves metabolic complications associated to morbid obesity, including dyslipidemia. Although the cholesterol-lowering effect varies with the bariatric procedures, the underlying molecular mechanisms remain poorly defined. This study aims to assess the consequence of both restrictive (sleeve gastrectomy; SG) and malabsorptive (Roux-en-Y gastric bypass; RYGB) procedures on cholesterol metabolism in mice.

Subjects: Ten-week-old C57BL6/J males were fed with a high-fat diet for 8-14 weeks before sleeve or RYGB surgery.

Results: SG has a modest and transient effect on plasma cholesterol levels, linked to a reduction in food intake. In contrast, modified RYGB led to a sustained ≈35% reduction in plasma cholesterol concentrations with a drastic increase in fecal cholesterol output. Mechanistically, RYGB exerts a synergystic effect on cholesterol metabolism by inducing the trans-intestinal cholesterol efflux and reducing the intestinal cholesterol absorption.

Conclusions: In mice, RYGB, but not sleeve, strongly favors plasma cholesterol elimination by concomitantly increasing trans-intestinal cholesterol excretion and by decreasing intestinal cholesterol absorption. Our models open new perspective for deciphering the hypocholesterolemic effects of bariatric procedures.

Citing Articles

Weight Loss Directly Influences Intermediate-Term Remission of Diabetes Mellitus After Bariatric Surgery: A Retrospective Case-Control Study.

de La Harpe R, Rueger S, Kutalik Z, Ballabeni P, Suter M, Vionnet N Obes Surg. 2019; 30(4):1332-1338.

PMID: 31754925 PMC: 10015445. DOI: 10.1007/s11695-019-04283-8.

Surgical Mouse Models of Vertical Sleeve Gastrectomy and Roux-en Y Gastric Bypass: a Review.

Stevenson M, Lee J, Lau R, Brathwaite C, Ragolia L Obes Surg. 2019; 29(12):4084-4094.

PMID: 31630327 DOI: 10.1007/s11695-019-04205-8.

Meal patterns after bariatric surgery in mice and rats.

Shah H, Shin A Appetite. 2019; 146:104340.

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Bariatric Surgery in Rats Upregulates FSP27 Expression in Fat Tissue to Affect Fat Hydrolysis and Metabolism.

Hu J, Wang M, Zhou Y, Zhang X, He B, Liu L Biomed Res Int. 2019; 2019:6415732.

PMID: 31205943 PMC: 6530210. DOI: 10.1155/2019/6415732.

Maternal Roux-en-Y gastric bypass impairs insulin action and endocrine pancreatic function in male F1 offspring.

Pietrobon C, Bertasso I, Ribeiro R, Alegre-Maller A, Lubaczeuski C, Boschero A Eur J Nutr. 2019; 59(3):1067-1079.

PMID: 30982179 DOI: 10.1007/s00394-019-01968-9.

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