Identification of Membrane Proteome of and Its Regulation by Zinc

Overview

Journal Future Sci OA

Specialty Biotechnology

Date 2017 Nov 15

PMID 29134119

Citations 14

Authors

Juliana Santana de Curcio

Marielle Garcia Silva

Mirelle Garcia Silva Bailao

Sonia Nair Bao

Luciana Casaletti

Alexandre Mello Bailao

Celia Maria de Almeida Soares

Affiliations

Soon will be listed here.

Abstract

Aim: During infection development in the host, spp. faces the deprivation of micronutrients, a mechanism called nutritional immunity. This condition induces the remodeling of proteins present in different metabolic pathways. Therefore, we attempted to identify membrane proteins and their regulation by zinc in .

Materials & Methods: Membranes enriched fraction of yeast cells of were isolated, purified and identified by 2D LC-MS/MS detection and database search.

Results & Conclusion: Zinc deprivation suppressed the expression of membrane proteins such as glycoproteins, those involved in cell wall synthesis and those related to oxidative phosphorylation. This is the first study describing membrane proteins and the effect of zinc deficiency in their regulation in one member of the genus .

Citing Articles

Zinc Starvation Induces Cell Wall Remodeling and Activates the Antioxidant Defense System in .

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Polypeptides Targeting Drk1.

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Global Molecular Response of to Zinc Deprivation: Analyses at Transcript, Protein and MicroRNA Levels.

Mesquita L, Bailao A, Santana de Curcio J, da Silva K, da Rocha Fernandes G, Silva-Bailao M J Fungi (Basel). 2023; 9(3).

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Nutritional immunity: targeting fungal zinc homeostasis.

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