Metabolomics-based Discovery of a Metabolite That Enhances Oligodendrocyte Maturation

Overview

Journal Nat Chem Biol

Specialties Biochemistry
Biology
Chemistry

Date 2017 Nov 14

PMID 29131145

Citations 39

Authors

Brittney A Beyer

Mingliang Fang

Benjamin Sadrian

J Rafael Montenegro-Burke

Warren C Plaisted

Bernard P C Kok

Enrique Saez

Toru Kondo

Gary Siuzdak

Luke L Lairson

Affiliations

Soon will be listed here.

Abstract

Endogenous metabolites play essential roles in the regulation of cellular identity and activity. Here we have investigated the process of oligodendrocyte precursor cell (OPC) differentiation, a process that becomes limiting during progressive stages of demyelinating diseases, including multiple sclerosis, using mass-spectrometry-based metabolomics. Levels of taurine, an aminosulfonic acid possessing pleotropic biological activities and broad tissue distribution properties, were found to be significantly elevated (∼20-fold) during the course of oligodendrocyte differentiation and maturation. When added exogenously at physiologically relevant concentrations, taurine was found to dramatically enhance the processes of drug-induced in vitro OPC differentiation and maturation. Mechanism of action studies suggest that the oligodendrocyte-differentiation-enhancing activities of taurine are driven primarily by its ability to directly increase available serine pools, which serve as the initial building block required for the synthesis of the glycosphingolipid components of myelin that define the functional oligodendrocyte cell state.

Citing Articles

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