Disease of MRNA Regulation: Relevance for Ischemic Brain Injury

Overview

Journal Transl Stroke Res

Publisher Springer

Date 2017 Nov 12

PMID 29127592

Citations 5

Authors

Donald J DeGracia

Affiliations

Soon will be listed here.

Abstract

In this mini-review we give an overview of the role of mRNA-binding proteins and their associated messenger ribonucleoprotein complexes (mRNPs) in several disease states, and bring this information to bear on the pathophysiology of brain ischemia. One conclusion reached is that mRNPs may play a causal role in proteotoxicity instead of being merely passive targets. Ischemia therapies targeting mRNPs have advantages over targeting single pathways, but the behavior of mRNPs needs to be considered in the design of therapies.

Citing Articles

LncRNA Taurine Up-Regulated 1 Knockout Provides Neuroprotection in Ischemic Stroke Rats by Inhibiting Nuclear-Cytoplasmic Shuttling of HuR.

Shi X, Liu S, Zou Y, Wu H, Ma J, Lin J Biomedicines. 2024; 12(11).

PMID: 39595085 PMC: 11592331. DOI: 10.3390/biomedicines12112520.

Post-ischemic ubiquitination at the postsynaptic density reversibly influences the activity of ischemia-relevant kinases.

Dhawka L, Palfini V, Hambright E, Blanco I, Poon C, Kahl A Commun Biol. 2024; 7(1):321.

PMID: 38480905 PMC: 10937959. DOI: 10.1038/s42003-024-06009-8.

New Drug Targets to Prevent Death Due to Stroke: A Review Based on Results of Protein-Protein Interaction Network, Enrichment, and Annotation Analyses.

Maes M, Nikiforov N, Plaimas K, Suratanee A, Alfieri D, Reiche E Int J Mol Sci. 2021; 22(22).

PMID: 34829993 PMC: 8619767. DOI: 10.3390/ijms222212108.

N-methyladenosine (mA) methylation in ischemia-reperfusion injury.

Yao W, Han X, Ge M, Chen C, Xiao X, Li H Cell Death Dis. 2020; 11(6):478.

PMID: 32581252 PMC: 7314846. DOI: 10.1038/s41419-020-2686-7.

Crotalus atrox disintegrin reduces hemorrhagic transformation by attenuating matrix metalloproteinase-9 activity after middle cerebral artery occlusion in hyperglycemic male rats.

McBride D, Gren E, Kelln W, Hayes W, Zhang J J Neurosci Res. 2018; 98(1):191-200.

PMID: 30242872 PMC: 6430696. DOI: 10.1002/jnr.24334.

References

Sharp F, Kinouchi H, Koistinaho J, Chan P, Sagar S . HSP70 heat shock gene regulation during ischemia. Stroke. 1993; 24(12 Suppl):I72-5. View

Liu C, Ge P, Zhang F, Hu B . Co-translational protein aggregation after transient cerebral ischemia. Neuroscience. 2005; 134(4):1273-84. PMC: 3424706. DOI: 10.1016/j.neuroscience.2005.05.015. View

Wang H, Anggraini F, Chen X, DeGracia D . Embryonic lethal abnormal vision proteins and adenine and uridine-rich element mRNAs after global cerebral ischemia and reperfusion in the rat. J Cereb Blood Flow Metab. 2016; 37(4):1494-1507. PMC: 5453468. DOI: 10.1177/0271678X16657572. View

Lloyd R . Translational control by viral proteinases. Virus Res. 2005; 119(1):76-88. PMC: 7173276. DOI: 10.1016/j.virusres.2005.10.016. View

Gilks N, Kedersha N, Ayodele M, Shen L, Stoecklin G, Dember L . Stress granule assembly is mediated by prion-like aggregation of TIA-1. Mol Biol Cell. 2004; 15(12):5383-98. PMC: 532018. DOI: 10.1091/mbc.e04-08-0715. View

Dabo S, Meurs E . dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection. Viruses. 2012; 4(11):2598-635. PMC: 3509664. DOI: 10.3390/v4112598. View

Ash P, Vanderweyde T, Youmans K, Apicco D, Wolozin B . Pathological stress granules in Alzheimer's disease. Brain Res. 2014; 1584:52-8. PMC: 4256948. DOI: 10.1016/j.brainres.2014.05.052. View

Kedersha N, Gupta M, Li W, Miller I, Anderson P . RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules. J Cell Biol. 1999; 147(7):1431-42. PMC: 2174242. DOI: 10.1083/jcb.147.7.1431. View

Harvey R, Dezi V, Pizzinga M, Willis A . Post-transcriptional control of gene expression following stress: the role of RNA-binding proteins. Biochem Soc Trans. 2017; 45(4):1007-14. PMC: 5655797. DOI: 10.1042/BST20160364. View

10.

Moeller B, Dewhirst M . Raising the bar: how HIF-1 helps determine tumor radiosensitivity. Cell Cycle. 2004; 3(9):1107-10. View

11.

Grammatikakis I, Abdelmohsen K, Gorospe M . Posttranslational control of HuR function. Wiley Interdiscip Rev RNA. 2016; 8(1). PMC: 5607777. DOI: 10.1002/wrna.1372. View

12.

Petrov T, Underwood B, Braun B, Alousi S, Rafols J . Upregulation of iNOS expression and phosphorylation of eIF-2alpha are paralleled by suppression of protein synthesis in rat hypothalamus in a closed head trauma model. J Neurotrauma. 2001; 18(8):799-812. DOI: 10.1089/089771501316919166. View

13.

Chou A, Krukowski K, Jopson T, Zhu P, Costa-Mattioli M, Walter P . Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury. Proc Natl Acad Sci U S A. 2017; 114(31):E6420-E6426. PMC: 5547647. DOI: 10.1073/pnas.1707661114. View

14.

Kayali F, Montie H, Rafols J, Degracia D . Prolonged translation arrest in reperfused hippocampal cornu Ammonis 1 is mediated by stress granules. Neuroscience. 2005; 134(4):1223-45. DOI: 10.1016/j.neuroscience.2005.05.047. View

15.

Cestra G, Rossi S, Di Salvio M, Cozzolino M . Control of mRNA Translation in ALS Proteinopathy. Front Mol Neurosci. 2017; 10:85. PMC: 5362592. DOI: 10.3389/fnmol.2017.00085. View

16.

Ayuso M, Martinez-Alonso E, Regidor I, Alcazar A . Stress Granule Induction after Brain Ischemia Is Independent of Eukaryotic Translation Initiation Factor (eIF) 2α Phosphorylation and Is Correlated with a Decrease in eIF4B and eIF4E Proteins. J Biol Chem. 2016; 291(53):27252-27264. PMC: 5207152. DOI: 10.1074/jbc.M116.738989. View

17.

Hu B, Janelidze S, Ginsberg M, Busto R, Perez-Pinzon M, Sick T . Protein aggregation after focal brain ischemia and reperfusion. J Cereb Blood Flow Metab. 2001; 21(7):865-75. DOI: 10.1097/00004647-200107000-00012. View

18.

Saarikangas J, Barral Y . Protein aggregation as a mechanism of adaptive cellular responses. Curr Genet. 2016; 62(4):711-724. DOI: 10.1007/s00294-016-0596-0. View

19.

Hossmann K . Disturbances of cerebral protein synthesis and ischemic cell death. Prog Brain Res. 1993; 96:161-77. DOI: 10.1016/s0079-6123(08)63265-3. View

20.

OCollins V, Macleod M, Donnan G, Horky L, van der Worp B, Howells D . 1,026 experimental treatments in acute stroke. Ann Neurol. 2006; 59(3):467-77. DOI: 10.1002/ana.20741. View