Recovery of Extracellular Matrix Components by Enalapril Maleate During the Repair Process of Ultraviolet B-induced Wrinkles in Mouse Skin

Overview

Journal Biochem Biophys Rep

Specialty Biochemistry

Date 2017 Nov 11

PMID 29124203

Citations 3

Authors

Yuko Matsuura-Hachiya

Yuji Nakai

Keiko Abe

Toshio Nishiyama

Koji Y Arai

Affiliations

Soon will be listed here.

Abstract

The renin-angiotensin system is known to be involved in skin remodeling and inflammation. Previously, we reported that ultraviolet B (UVB) irradiation enhanced angiotensin-converting enzyme (ACE) expression and angiotensin II levels in hairless mouse skin, and an ACE inhibitor, enalapril maleate (EM), accelerated repair of UVB-induced wrinkles. In this study, we analyzed gene expression profiles by DNA microarray and protein distribution patterns using an immunofluorescence method to clarify the process of EM-accelerated wrinkle repair in UVB-irradiated hairless mouse skin. In the microarray analysis, we detected EM-induced up-regulation of various extracellular matrix (ECM)-related genes in the UVB-irradiated skin. In the immunofluorescence, we confirmed that type I collagen α1 chain, fibrillin 1, elastin and dystroglycan 1 in the skin decreased after repeated UVB irradiation but staining for these proteins was improved by EM treatment. In addition, ADAMTS2 and MMP-14 also increased in the EM-treated skin. Although the relationship between these molecules and wrinkle formation is not clear yet, our present data suggest that the molecules are involved in the repair of UVB-induced wrinkles.

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