Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach

Overview

Journal J Trop Med

Publisher Wiley

Specialty Tropical Medicine

Date 2017 Nov 11

PMID 29123551

Citations 3

Authors

Siti Junaidah Ahmad

Mohd Badrin Hanizam Abdul Rahim

Syarul Nataqain Baharum

Mohd Shukri Baba

Noraziah Mohamad Zin

Affiliations

Soon will be listed here.

Abstract

Natural products continue to play an important role as a source of biologically active substances for the development of new drug. , Gram-positive bacteria which are widely distributed in nature, are one of the most popular sources of natural antibiotics. Recently, by using a bioassay-guided fractionation, an antimalarial compound, Gancidin-W, has been discovered from these bacteria. However, this classical method in identifying potentially novel bioactive compounds from the natural products requires considerable effort and is a time-consuming process. Metabolomics is an emerging "omics" technology in systems biology study which integrated in process of discovering drug from natural products. Metabolomics approach in finding novel therapeutics agent for malaria offers dereplication step in screening phase to shorten the process. The highly sensitive instruments, such as Liquid Chromatography-Mass Spectrophotometry (LC-MS), Gas Chromatography-Mass Spectrophotometry (GC-MS), and Nuclear Magnetic Resonance (H-NMR) spectroscopy, provide a wide range of information in the identification of potentially bioactive compounds. The current paper reviews concepts of metabolomics and its application in drug discovery of malaria treatment as well as assessing the antimalarial activity from natural products. Metabolomics approach in malaria drug discovery is still new and needs to be initiated, especially for drug research in Malaysia.

Citing Articles

Discovery of antimalarial drugs from secondary metabolites in actinomycetes culture library.

Teklemichael A, Teshima A, Hirata A, Akimoto M, Taniguchi M, Khodakaramian G Trop Med Health. 2024; 52(1):47.

PMID: 38982547 PMC: 11232162. DOI: 10.1186/s41182-024-00608-1.

Fractions 14 and 36K of Metabolite Extract subsp. Hygroscopicus Have Antimalarial Activities Against in vitro.

Fitri L, Endharti A, Abidah H, Khotimah A, Endrawati H Infect Drug Resist. 2023; 16:2973-2985.

PMID: 37201124 PMC: 10187656. DOI: 10.2147/IDR.S400538.

Metabolomic study of marine Streptomyces sp.: Secondary metabolites and the production of potential anticancer compounds.

Tangerina M, Furtado L, Leite V, Bauermeister A, Velasco-Alzate K, Jimenez P PLoS One. 2020; 15(12):e0244385.

PMID: 33347500 PMC: 7751980. DOI: 10.1371/journal.pone.0244385.

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