Molecular Analysis of Axonal-intrinsic and Glial-associated Co-regulation of Axon Degeneration

Overview

Journal Cell Death Dis

Specialties Cell Biology
General Medicine

Date 2017 Nov 10

PMID 29120410

Citations 31

Authors

Alejandra Catenaccio

Maica Llavero Hurtado

Paula Diaz

Douglas J Lamont

Thomas M Wishart

Felipe A Court

Affiliations

Soon will be listed here.

Abstract

Wallerian degeneration is an active program tightly associated with axonal degeneration, required for axonal regeneration and functional recovery after nerve damage. Here we provide a functional molecular foundation for our undertstanding of the complex non-cell autonomous role of glial cells in the regulation of axonal degeneration. To shed light on the complexity of the molecular machinery governing axonal degeneration we employ a multi-model, unbiased, in vivo approach combining morphological assesment and quantitative proteomics with in silico-based higher order functional clustering to genetically uncouple the intrinsic and extrinsic processes governing Wallerian degeneration. Highlighting a pivotal role for glial cells in the early stages fragmenting the axon by a cytokinesis-like process and a cell autonomous stage of axonal disintegration associated to mitochondrial dysfunction.

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