Nuclear Magnetic Resonance Spectroscopy As a New Approach for Improvement of Early Diagnosis and Risk Stratification of Prostate Cancer

Overview

Journal J Zhejiang Univ Sci B

Specialties Biology
General Medicine

Date 2017 Nov 10

PMID 29119730

Citations 7

Authors

Bo Yang

Guo-Qiang Liao

Xiao-Fei Wen

Wei-Hua Chen

Sheng Cheng

Jens-Uwe Stolzenburg

Roman Ganzer

Jochen Neuhaus

Affiliations

Soon will be listed here.

Abstract

Prostate cancer (PCa) is the second most common male cancer worldwide and the fifth leading cause of death from cancer in men. Early detection and risk stratification is the most effective way to improve the survival of PCa patients. Current PCa biomarkers lack sufficient sensitivity and specificity to cancer. Metabolite biomarkers are evolving as a new diagnostic tool. This review is aimed to evaluate the potential of metabolite biomarkers for early detection, risk assessment, and monitoring of PCa. Of the 154 identified publications, 27 and 38 were original papers on urine and serum metabolomics, respectively. Nuclear magnetic resonance (NMR) is a promising method for measuring concentrations of metabolites in complex samples with good reproducibility, high sensitivity, and simple sample processing. Especially urine-based NMR metabolomics has the potential to be a cost-efficient method for the early detection of PCa, risk stratification, and monitoring treatment efficacy.

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