The Role of Endotoxin in the Setting of Cardiorenal Syndrome Type 5

Overview

Journal Cardiorenal Med

Publisher Karger

Specialties Cardiology & Vascular Diseases
Endocrinology
Nephrology

Date 2017 Nov 10

PMID 29118766

Citations 5

Authors

Anna Clementi

Grazia Maria Virzi

Alessandra Brocca

Claudio Ronco

Affiliations

Soon will be listed here.

Abstract

Lipopolysaccharide or endotoxin, the major cell wall component of gram-negative bacteria, plays a pivotal role in the pathogenesis of sepsis. It is able to activate the host defense system through the interaction with Toll-like receptor 4, thus triggering pro-inflammatory mechanisms. When the production of inflammatory mediators becomes uncontrolled and excessive, septic shock develops with multiple organ dysfunction, such as myocardial and renal impairment, which are hallmarks of cardiorenal syndrome type 5. In this review, we will analyze the role of endotoxin in the pathogenesis of sepsis, its effects on cardiac and renal interactions in the setting of cardiorenal syndrome type 5 and the possible use of extracorporeal therapies in this clinical condition.

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References

Reilly J, Cunnion R, Parker M, Shelhamer J, Parrillo J . A circulating myocardial depressant substance is associated with cardiac dysfunction and peripheral hypoperfusion (lactic acidemia) in patients with septic shock. Chest. 1989; 95(5):1072-80. DOI: 10.1378/chest.95.5.1072. View

Cohen R, Hassell A, Marzouk K, Marini C, Liu S, Scharf S . Renal effects of nitric oxide in endotoxemia. Am J Respir Crit Care Med. 2001; 164(10 Pt 1):1890-5. DOI: 10.1164/ajrccm.164.10.2103140. View

Tavernier B, Li J, Lanone S, Yang Z, Trayer I, Mebazaa A . Cardiac contractile impairment associated with increased phosphorylation of troponin I in endotoxemic rats. FASEB J. 2001; 15(2):294-6. DOI: 10.1096/fj.00-0433fje. View

Jacobs R, Honore P, Joannes-Boyau O, Boer W, De Regt J, De Waele E . Septic acute kidney injury: the culprit is inflammatory apoptosis rather than ischemic necrosis. Blood Purif. 2011; 32(4):262-5. DOI: 10.1159/000330244. View

Cantaluppi V, Weber V, Lauritano C, Figliolini F, Beltramo S, Biancone L . Protective effect of resin adsorption on septic plasma-induced tubular injury. Crit Care. 2010; 14(1):R4. PMC: 2875506. DOI: 10.1186/cc8835. View

KHAN R, Badr K . Endotoxin and renal function: perspectives to the understanding of septic acute renal failure and toxic shock. Nephrol Dial Transplant. 1999; 14(4):814-8. DOI: 10.1093/ndt/14.4.814. View

Ianaro A, Tersigni M, DAcquisto F . New insight in LPS antagonist. Mini Rev Med Chem. 2009; 9(3):306-17. DOI: 10.2174/1389557510909030306. View

Ronco C, Haapio M, House A, Anavekar N, Bellomo R . Cardiorenal syndrome. J Am Coll Cardiol. 2008; 52(19):1527-39. DOI: 10.1016/j.jacc.2008.07.051. View

Guo R, Wang Y, Minto A, Quigg R, Cunningham P . Acute renal failure in endotoxemia is dependent on caspase activation. J Am Soc Nephrol. 2004; 15(12):3093-102. DOI: 10.1097/01.ASN.0000145530.73247.F5. View

10.

Schromm A, Lien E, Henneke P, Chow J, Yoshimura A, Heine H . Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling. J Exp Med. 2001; 194(1):79-88. PMC: 2193443. DOI: 10.1084/jem.194.1.79. View

11.

Good D, George T, Watts 3rd B . Toll-like receptor 2 mediates inhibition of HCO(3)(-) absorption by bacterial lipoprotein in medullary thick ascending limb. Am J Physiol Renal Physiol. 2010; 299(3):F536-44. PMC: 2944297. DOI: 10.1152/ajprenal.00108.2010. View

12.

Morrison D, Jacobs D . Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharides. Immunochemistry. 1976; 13(10):813-8. DOI: 10.1016/0019-2791(76)90181-6. View

13.

Li J, Nation R, Turnidge J, Milne R, Coulthard K, Rayner C . Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections. Lancet Infect Dis. 2006; 6(9):589-601. DOI: 10.1016/S1473-3099(06)70580-1. View

14.

Molitoris B . Renal blood flow in sepsis: a complex issue. Crit Care. 2005; 9(4):327-8. PMC: 1269462. DOI: 10.1186/cc3740. View

15.

Tavener S, Long E, Robbins S, McRae K, Van Remmen H, Kubes P . Immune cell Toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia. Circ Res. 2004; 95(7):700-7. DOI: 10.1161/01.RES.0000144175.70140.8c. View

16.

Lefer A . Mechanisms of cardiodepression in endotoxin shock. Circ Shock Suppl. 1979; 1:1-8. View

17.

Lerolle N, Nochy D, Guerot E, Bruneval P, Fagon J, Diehl J . Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltration. Intensive Care Med. 2009; 36(3):471-8. DOI: 10.1007/s00134-009-1723-x. View

18.

Opal S, Laterre P, Francois B, LaRosa S, Angus D, Mira J . Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA. 2013; 309(11):1154-62. DOI: 10.1001/jama.2013.2194. View

19.

Cruz D, Perazella M, Bellomo R, De Cal M, Polanco N, Corradi V . Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review. Crit Care. 2007; 11(2):R47. PMC: 2206475. DOI: 10.1186/cc5780. View

20.

Wu L, Tiwari M, Messer K, Holthoff J, Gokden N, Brock R . Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in mice. Am J Physiol Renal Physiol. 2006; 292(1):F261-8. DOI: 10.1152/ajprenal.00263.2006. View