Looking Beyond the Cyclosporine "Swish and Spit" Technique in a Recalcitrant Case of Erosive Lichen Planus Involving the Tongue

Overview

Journal Case Rep Dermatol

Publisher Karger

Specialty Dermatology

Date 2017 Nov 10

PMID 29118700

Citations 3

Authors

Aastha Gupta

Kabir Sardana

Ram Kishan Gautam

Affiliations

Soon will be listed here.

Abstract

Oral lichen planus is a relatively common autoimmune disease affecting the middle-aged population. Although no treatment is necessary for a benign asymptomatic case, in case of erosive lichen planus, topical corticosteroids form the mainstay of treatment. In case of failure, apart from tacrolimus, cyclosporine, using the "swish and spit" technique, is a valid therapeutic intervention. In our case, though, this therapeutic option had to be replaced by the systemic use of cyclosporine with gratifying results.

Citing Articles

Integrative Approaches for the Diagnosis and Management of Erosive Oral Lichen Planus.

Popa C, Sciuca A, Onofrei B, Toader S, Condurache Hritcu O, Botoc Colac C Diagnostics (Basel). 2024; 14(7).

PMID: 38611605 PMC: 11011293. DOI: 10.3390/diagnostics14070692.

Oral manifestations of iron imbalance.

Anne Marie U, Murererehe J, Rehman M, Chittilla M, Uwambaye P, Razzaque M Front Nutr. 2023; 10:1272902.

PMID: 37899821 PMC: 10611504. DOI: 10.3389/fnut.2023.1272902.

A randomized clinical trial of topical dexamethasone vs. cyclosporine treatment for oral lichen planus.

Georgaki M, Piperi E, Theofilou V, Pettas E, Stoufi E, Nikitakis N Med Oral Patol Oral Cir Bucal. 2021; 27(2):e113-e124.

PMID: 34564686 PMC: 8898582. DOI: 10.4317/medoral.25040.

References

Ibrahim S, Hazzaa H . Topical pimecrolimus effect on Fas inducing apoptosis in oral lichen planus: a clinical immunohistochemical study. J Oral Pathol Med. 2011; 41(4):315-21. DOI: 10.1111/j.1600-0714.2011.01099.x. View

Beck H, Brandrup F . Treatment of erosive lichen planus with dapsone. Acta Derm Venereol. 1986; 66(4):366-7. View

Sieg P, Domarus H, Von Zitzewitz V, Iven H, Farber L . Topical cyclosporin in oral lichen planus: a controlled, randomized, prospective trial. Br J Dermatol. 1995; 132(5):790-4. DOI: 10.1111/j.1365-2133.1995.tb00728.x. View

van der Hem P, Egges M, van der Wal J, Roodenburg J . CO2 laser evaporation of oral lichen planus. Int J Oral Maxillofac Surg. 2008; 37(7):630-3. DOI: 10.1016/j.ijom.2008.04.011. View

Naukkarinen A, Vaatainen N, Syrjanen K, Horsmanheimo M . Immunophenotyping of the dermal cell infiltrate in lichen planus treated with PUVA. Acta Derm Venereol. 1985; 65(5):398-402. View

Loitz G, Oleary J . Erosive lichen planus of the tongue treated by cryosurgery. J Oral Maxillofac Surg. 1986; 44(7):580-2. DOI: 10.1016/s0278-2391(86)80103-3. View

Mozzanica N, Cattaneo A, Legori A, Pigatto P, Finzi A . Immunohistologic evaluation of the effect of cyclosporine treatment on the lichen planus immune infiltrate. J Am Acad Dermatol. 1991; 24(4):550-4. DOI: 10.1016/0190-9622(91)70080-l. View

Itin P, Surber C, Buchner S . Lack of effect after local treatment with a new ciclosporin formulation in recalcitrant erosive oral lichen planus. Dermatology. 1992; 185(4):262-5. DOI: 10.1159/000247464. View

Piattelli A, Carinci F, Iezzi G, Perrotti V, Goteri G, Fioroni M . Oral lichen planus treated with 13-cis-retinoic acid (isotretinoin): effects on the apoptotic process. Clin Oral Investig. 2007; 11(3):283-8. DOI: 10.1007/s00784-007-0117-0. View

10.

Krupaa R, Sankari S, Masthan K, Rajesh E . Oral lichen planus: An overview. J Pharm Bioallied Sci. 2015; 7(Suppl 1):S158-61. PMC: 4439656. DOI: 10.4103/0975-7406.155873. View

11.

Boyce A, Marshman G, Mills R . Erosive mucosal lichen planus and secondary epiphora responding to systemic cyclosporin A treatment. Australas J Dermatol. 2009; 50(3):190-3. DOI: 10.1111/j.1440-0960.2009.00536.x. View

12.

Sulewska M, Duraj E, Sobaniec S, Graczyk A, Milewski R, Wroblewska M . A clinical evaluation of the efficacy of photodynamic therapy in the treatment of erosive oral lichen planus: A case series. Photodiagnosis Photodyn Ther. 2017; 18:12-19. DOI: 10.1016/j.pdpdt.2017.01.178. View

13.

Lavanya N, Jayanthi P, Rao U, Ranganathan K . Oral lichen planus: An update on pathogenesis and treatment. J Oral Maxillofac Pathol. 2012; 15(2):127-32. PMC: 3329692. DOI: 10.4103/0973-029X.84474. View

14.

Carbone M, Goss E, Carrozzo M, Castellano S, Conrotto D, Broccoletti R . Systemic and topical corticosteroid treatment of oral lichen planus: a comparative study with long-term follow-up. J Oral Pathol Med. 2003; 32(6):323-9. DOI: 10.1034/j.1600-0714.2003.00173.x. View

15.

Kazancioglu H, Erisen M . Comparison of Low-Level Laser Therapy versus Ozone Therapy in the Treatment of Oral Lichen Planus. Ann Dermatol. 2015; 27(5):485-91. PMC: 4622881. DOI: 10.5021/ad.2015.27.5.485. View

16.

Takeuchi Y, Tohnai I, Kaneda T, Nagura H . Immunohistochemical analysis of cells in mucosal lesions of oral lichen planus. J Oral Pathol. 1988; 17(8):367-73. DOI: 10.1111/j.1600-0714.1988.tb01299.x. View

17.

Surber C, Itin P, Buchner S . Clinical controversy on the effect of topical ciclosporin: what is the target site?. Dermatology. 1992; 185(4):242-5. DOI: 10.1159/000247460. View

18.

Gupta S, Jawanda M . Oral Lichen Planus: An Update on Etiology, Pathogenesis, Clinical Presentation, Diagnosis and Management. Indian J Dermatol. 2015; 60(3):222-9. PMC: 4458931. DOI: 10.4103/0019-5154.156315. View