Improving Neurorepair in Stroke Brain Through Endogenous Neurogenesis-Enhancing Drugs

Overview

Journal Cell Transplant

Specialties Cell Biology
General Surgery

Date 2017 Nov 9

PMID 29113469

Citations 18

Authors

Kuo-Jen Wu

Seongjin Yu

Jea-Young Lee

Barry Hoffer

Yun Wang

Affiliations

Soon will be listed here.

Abstract

Stroke induces not only cell death but also neurorepair. De novo neurogenesis has been found in the subventricular zone of the adult mammalian brain days after stroke. Most of these newly generated cells die shortly after the insult. Recent studies have shown that pharmacological manipulation can improve the survival of endogenous neuroprogenitor cells and neural regeneration in stroke rats. As these drugs target the endogenous reparative processes that occur days after stroke, they may provide a prolonged window for stroke therapy. Here, we discuss endogenous neurogenesis-enhancing drugs and review the general status of stroke therapeutics in evaluating the field of pharmacotherapy for stroke.

Citing Articles

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Endogenous Neural Stem Cell-induced Neurogenesis after Ischemic Stroke: Processes for Brain Repair and Perspectives.

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