View Point: Semaphorin-3E: An Emerging Modulator of Natural Killer Cell Functions?

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2017 Nov 9

PMID 29113093

Citations 7

Authors

Abdulaziz Alamri

Abdelilah Soussi Gounni

Sam K P Kung

Affiliations

Soon will be listed here.

Abstract

Semaphorin-3E (Sema-3E) is a member of a large family of proteins originally identified as axon guidance cues in neural development. It is expressed in different cell types, such as immune cells, cancer cells, neural cells, and epithelial cells. Subsequently, dys-regulation of Sema-3E expression has been reported in various biological processes that range from cancers to autoimmune and allergic diseases. Recent work in our laboratories revealed a critical immunoregulatory role of Sema-3E in experimental allergic asthma. We further speculate possible immune modulatory function(s) of Sema-3E on natural killer (NK) cells.

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