Associated Conditions in Small Fiber Neuropathy - a Large Cohort Study and Review of the Literature

Overview

Journal Eur J Neurol

Publisher Wiley

Specialty Neurology

Date 2017 Nov 8

PMID 29112785

Citations 55

Authors

B T A de Greef

J G J Hoeijmakers

C M L Gorissen-Brouwers

M Geerts

C G Faber

I S J Merkies

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Small fiber neuropathy (SFN) is a common disorder leading to neuropathic pain and autonomic symptoms. The objective of this study was to investigate associated conditions in a large cohort of SFN patients and compare the prevalence to healthy individuals.

Methods: A total of 921 patients with pure SFN were screened according to a standardized comprehensive diagnostic algorithm and compared with literature findings.

Results: No associated condition could be found in 53% of the patients. Autoimmune diseases, sodium channel gene mutations, diabetes mellitus including glucose intolerance, and vitamin B12 deficiencies were more prevalent than reported literature findings, followed by alcohol abuse, chemotherapy, monoclonal gammopathy of undetermined significance, and haemochromatosis. In patients who were already known with a possible underlying condition at screening, additional underlying conditions were still found in another 26.7% of patients.

Conclusions: Based on these results, it is recommended that patients with pure SFN are screened at least for autoimmune diseases, sodium channel gene mutations, diabetes mellitus including glucose intolerance, and vitamin B12 deficiency, even when they already have a potential underlying condition at referral.

Citing Articles

The Experience Sampling Method in Small Fiber Neuropathy: The Influence of Psychosocial Factors on Pain Intensity and Physical Activity.

Damci A, Hoeijmakers J, den Hollander M, Faber C, Waardenburg S, van Laake-Geelen C J Pain Res. 2024; 17:3997-4010.

PMID: 39619214 PMC: 11606713. DOI: 10.2147/JPR.S481274.

Biopsychosocial rehabilitation therapy in small fiber neuropathy: research protocol to study the effect of rehabilitation treatment.

Damci A, den Hollander M, Hoeijmakers J, Faber C, Goossens M, Verbunt J Front Neurol. 2024; 15:1493326.

PMID: 39606707 PMC: 11598920. DOI: 10.3389/fneur.2024.1493326.

A Systematic Review of Dietary Lifestyle Interventions for Neuropathic Pain.

Klowak M, Lau R, Mohammed M, Birago A, Samson B, Ahmed L J Clin Med. 2024; 13(22).

PMID: 39597910 PMC: 11594944. DOI: 10.3390/jcm13226766.

Scleritis and episcleritis in patients with idiopathic small fiber neuropathy.

Apivatthakakul A, Liu R, Megalla M, Brill D, Sobrin L Am J Ophthalmol Case Rep. 2024; 36:102218.

PMID: 39583294 PMC: 11582542. DOI: 10.1016/j.ajoc.2024.102218.

Autoantibodies in neuromuscular disorders: a review of their utility in clinical practice.

Loser V, Vicino A, Theaudin M Front Neurol. 2024; 15:1495205.

PMID: 39555481 PMC: 11565704. DOI: 10.3389/fneur.2024.1495205.

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