Skin Surface PH in Acne Vulgaris: Insights from an Observational Study and Review of the Literature

Overview

Journal J Clin Aesthet Dermatol

Date 2017 Nov 7

PMID 29104722

Citations 23

Authors

Chaitra Prakash

Puneet Bhargava

Siddhi Tiwari

Banashree Majumdar

Rishi Kumar Bhargava

Affiliations

Soon will be listed here.

Abstract

Recurrent and chronic course of acne vulgaris, despite effect-proven therapies, point to an underfocused aspect in its pathogenesis and management. This study aims to assess in subjects with and without acne, the skin surface pH, a parameter that cumulatively represents functioning of various units of skin, including the barrier. A total of 200 patients with acne and 200 age- and sex-matched controls were included. Under basal conditions, facial skin pH was derived from five sites using a skin pH-meter. The relation between skin pH and acne was evaluated according to sex. There were more subjects with normal skin pH in the control group compared to the case group, and the majority of acne occurrences in the case group were related to high skin pH (=0.000). Mean pH among cases was higher than normal reference value (pH 4.5-5.5 for women, 4-5.5 for men) and that of controls (<0.001). No significant association was observed between sex and skin pH in either cases or controls (>0.05). Increased facial skin pH in patients with acne at basal conditions mirrors a chronic state of stratum corneum instability, which could be predisposing individuals to acne occurrence and/or recurrences. It could possibly be a common domain via which the classical pathomechanisms might be acting in acne. Integrating measures that maintain stratum corneum pH during therapy might prove worthwhile.

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References

Kim M, Choi S, Byun H, Huh C, Park K, Patel R . Comparison of sebum secretion, skin type, pH in humans with and without acne. Arch Dermatol Res. 2006; 298(3):113-9. DOI: 10.1007/s00403-006-0666-0. View

Seidenari S, Francomano M, Mantovani L . Baseline biophysical parameters in subjects with sensitive skin. Contact Dermatitis. 1998; 38(6):311-5. DOI: 10.1111/j.1600-0536.1998.tb05764.x. View

Korting H, Kerscher M, Schafer-Korting M, Berchtenbreiter U . Influence of topical erythromycin preparations for acne vulgaris on skin surface pH. Clin Investig. 1993; 71(8):644-8. DOI: 10.1007/BF00184493. View

Le Fur I, Reinberg A, Lopez S, Morizot F, Mechkouri M, Tschachler E . Analysis of circadian and ultradian rhythms of skin surface properties of face and forearm of healthy women. J Invest Dermatol. 2001; 117(3):718-24. DOI: 10.1046/j.0022-202x.2001.01433.x. View

Holland D, Cunliffe W . Skin surface and open comedone pH in acne patients. Acta Derm Venereol. 1983; 63(2):155-8. View

Fluhr J, Kao J, Jain M, Ahn S, Feingold K, Elias P . Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity. J Invest Dermatol. 2001; 117(1):44-51. DOI: 10.1046/j.0022-202x.2001.01399.x. View

Hachem J, Man M, Crumrine D, Uchida Y, Brown B, Rogiers V . Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity. J Invest Dermatol. 2005; 125(3):510-20. DOI: 10.1111/j.0022-202X.2005.23838.x. View

Schittek B, Hipfel R, Sauer B, Bauer J, Kalbacher H, Stevanovic S . Dermcidin: a novel human antibiotic peptide secreted by sweat glands. Nat Immunol. 2001; 2(12):1133-7. DOI: 10.1038/ni732. View

Reddy M, Wang X, Quinton P . Effect of cytosolic pH on epithelial Na+ channel in normal and cystic fibrosis sweat ducts. J Membr Biol. 2008; 225(1-3):1-11. DOI: 10.1007/s00232-008-9126-4. View

10.

Herrmann F, MANDOL L . Studies of pH of sweat produced by different forms of stimulation. J Invest Dermatol. 1955; 24(3):225-46. DOI: 10.1038/jid.1955.36. View

11.

Korting H, Kober M, Mueller M, Braun-Falco O . Influence of repeated washings with soap and synthetic detergents on pH and resident flora of the skin of forehead and forearm. Results of a cross-over trial in health probationers. Acta Derm Venereol. 1987; 67(1):41-7. View

12.

Mauro T, Holleran W, Grayson S, Gao W, Man M, Kriehuber E . Barrier recovery is impeded at neutral pH, independent of ionic effects: implications for extracellular lipid processing. Arch Dermatol Res. 1998; 290(4):215-22. DOI: 10.1007/s004030050293. View

13.

Sparavigna A, Tenconi B, De Ponti I, La Penna L . An innovative approach to the topical treatment of acne. Clin Cosmet Investig Dermatol. 2015; 8:179-85. PMC: 4399783. DOI: 10.2147/CCID.S82859. View

14.

Raphael K, Murphy R, Shlipak M, Satterfield S, Huston H, Sebastian A . Bicarbonate Concentration, Acid-Base Status, and Mortality in the Health, Aging, and Body Composition Study. Clin J Am Soc Nephrol. 2016; 11(2):308-16. PMC: 4741040. DOI: 10.2215/CJN.06200615. View

15.

Kim E, Kim S, Nam G, Lee H, Moon S, Chang I . The alkaline pH-adapted skin barrier is disrupted severely by SLS-induced irritation. Int J Cosmet Sci. 2009; 31(4):263-9. DOI: 10.1111/j.1468-2494.2009.00491.x. View

16.

Youn S, Choi C, Choi J, Youn S . The skin surface pH and its different influence on the development of acne lesion according to gender and age. Skin Res Technol. 2013; 19(2):131-6. DOI: 10.1111/srt.12023. View

17.

Thune P, Nilsen T, Hanstad I, Gustavsen T, Lovig Dahl H . The water barrier function of the skin in relation to the water content of stratum corneum, pH and skin lipids. The effect of alkaline soap and syndet on dry skin in elderly, non-atopic patients. Acta Derm Venereol. 1988; 68(4):277-83. View

18.

Chapman S, Walsh A . Membrane-coating granules are acidic organelles which possess proton pumps. J Invest Dermatol. 1989; 93(4):466-70. DOI: 10.1111/1523-1747.ep12284032. View

19.

Krien P, Kermici M . Evidence for the existence of a self-regulated enzymatic process within the human stratum corneum -an unexpected role for urocanic acid. J Invest Dermatol. 2000; 115(3):414-20. DOI: 10.1046/j.1523-1747.2000.00083.x. View

20.

Ohman H, Vahlquist A . The pH gradient over the stratum corneum differs in X-linked recessive and autosomal dominant ichthyosis: a clue to the molecular origin of the "acid skin mantle"?. J Invest Dermatol. 1998; 111(4):674-7. DOI: 10.1046/j.1523-1747.1998.00356.x. View