Examining the Relationship Between Trace Lithium in Drinking Water and the Rising Rates of Age-Adjusted Alzheimer's Disease Mortality in Texas

Overview

Journal J Alzheimers Dis

Publisher Sage Publications

Specialties Geriatrics
Neurology

Date 2017 Nov 6

PMID 29103043

Citations 31

Authors

Val Andrew Fajardo

Val Andrei Fajardo

Paul J LeBlanc

Rebecca E K MacPherson

Affiliations

Soon will be listed here.

Abstract

Background: Alzheimer's disease (AD) mortality rates have steadily increased over time. Lithium, the current gold standard treatment for bipolar disorder, can exert neuroprotective effects against AD.

Objective: We examined the relationship between trace levels of lithium in drinking water and changes in AD mortality across several Texas counties.

Methods: 6,180 water samples from public wells since 2007 were obtained and averaged for 234 of 254 Texas counties. Changes in AD mortality rates were calculated by subtracting aggregated age-adjusted mortality rates obtained between 2000-2006 from those obtained between 2009-2015. Using aggregated rates maximized the number of counties with reliable mortality data. Correlational analyses between average lithium concentrations and changes in AD mortality were performed while also adjusting for gender, race, education, rural living, air pollution, physical inactivity, obesity, and type 2 diabetes.

Results: Age-adjusted AD mortality rate was significantly increased over time (+27%, p < 0.001). Changes in AD mortality were negatively correlated with trace lithium levels (p = 0.01, r = -0.20), and statistical significance was maintained after controlling for most risk factors except for physical inactivity, obesity, and type 2 diabetes. Furthermore, the prevalence of obesity and type 2 diabetes positively correlated with changes in AD mortality (p = 0.01 and 0.03, respectively), but also negatively correlated with trace lithium in drinking water (p = 0.05 and <0.0001, respectively).

Conclusion: Trace lithium in water is negatively linked with changes in AD mortality, as well as obesity and type 2 diabetes, which are important risk factors for AD.

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References

Whitmer R . Type 2 diabetes and risk of cognitive impairment and dementia. Curr Neurol Neurosci Rep. 2007; 7(5):373-80. DOI: 10.1007/s11910-007-0058-7. View

Hill J, Stuht J, Wyatt H, Regensteiner J . Physical activity in prevention and management of obesity and type-2 diabetes. Nestle Nutr Workshop Ser Clin Perform Programme. 2006; 11:183-196. DOI: 10.1159/000094451. View

Ahmed S, Mahmood Z, Zahid S . Linking insulin with Alzheimer's disease: emergence as type III diabetes. Neurol Sci. 2015; 36(10):1763-9. DOI: 10.1007/s10072-015-2352-5. View

Taylor C, Greenlund S, McGuire L, Lu H, Croft J . Deaths from Alzheimer's Disease - United States, 1999-2014. MMWR Morb Mortal Wkly Rep. 2017; 66(20):521-526. PMC: 5657871. DOI: 10.15585/mmwr.mm6620a1. View

Naderali E, Ratcliffe S, Dale M . Obesity and Alzheimer's disease: a link between body weight and cognitive function in old age. Am J Alzheimers Dis Other Demen. 2009; 24(6):445-9. PMC: 10846277. DOI: 10.1177/1533317509348208. View

Reeve A, Simcox E, Turnbull D . Ageing and Parkinson's disease: why is advancing age the biggest risk factor?. Ageing Res Rev. 2014; 14:19-30. PMC: 3989046. DOI: 10.1016/j.arr.2014.01.004. View

Vina J, Lloret A . Why women have more Alzheimer's disease than men: gender and mitochondrial toxicity of amyloid-beta peptide. J Alzheimers Dis. 2010; 20 Suppl 2:S527-33. DOI: 10.3233/JAD-2010-100501. View

James B, Leurgans S, Hebert L, Scherr P, Yaffe K, Bennett D . Contribution of Alzheimer disease to mortality in the United States. Neurology. 2014; 82(12):1045-50. PMC: 3962992. DOI: 10.1212/WNL.0000000000000240. View

Feng Z, Donnelly L, Li J, Krishnamurthy M, Riopel M, Wang R . Inhibition of Gsk3β activity improves β-cell function in c-KitWv/+ male mice. Lab Invest. 2012; 92(4):543-55. PMC: 3940483. DOI: 10.1038/labinvest.2011.200. View

10.

Block M, Elder A, Auten R, Bilbo S, Chen H, Chen J . The outdoor air pollution and brain health workshop. Neurotoxicology. 2012; 33(5):972-84. PMC: 3726250. DOI: 10.1016/j.neuro.2012.08.014. View

11.

Hayes C, Kriska A . Role of physical activity in diabetes management and prevention. J Am Diet Assoc. 2008; 108(4 Suppl 1):S19-23. DOI: 10.1016/j.jada.2008.01.016. View

12.

Russ T, Batty G, Hearnshaw G, Fenton C, Starr J . Geographical variation in dementia: systematic review with meta-analysis. Int J Epidemiol. 2012; 41(4):1012-32. PMC: 3429875. DOI: 10.1093/ije/dys103. View

13.

Rondeau V, Commenges D, Jacqmin-Gadda H, Dartigues J . Relation between aluminum concentrations in drinking water and Alzheimer's disease: an 8-year follow-up study. Am J Epidemiol. 2000; 152(1):59-66. PMC: 2215380. DOI: 10.1093/aje/152.1.59. View

14.

Gitlin M . Lithium side effects and toxicity: prevalence and management strategies. Int J Bipolar Disord. 2016; 4(1):27. PMC: 5164879. DOI: 10.1186/s40345-016-0068-y. View

15.

Nunes M, Viel T, Buck H . Microdose lithium treatment stabilized cognitive impairment in patients with Alzheimer's disease. Curr Alzheimer Res. 2012; 10(1):104-7. DOI: 10.2174/1567205011310010014. View

16.

Hoyert D, Rosenberg H . Alzheimer's disease as a cause of death in the United States. Public Health Rep. 2000; 112(6):497-505. PMC: 1381929. View

17.

Macko A, Beneze A, Teachey M, Henriksen E . Roles of insulin signalling and p38 MAPK in the activation by lithium of glucose transport in insulin-resistant rat skeletal muscle. Arch Physiol Biochem. 2008; 114(5):331-9. PMC: 2633930. DOI: 10.1080/13813450802536067. View

18.

Kapusta N, Mossaheb N, Etzersdorfer E, Hlavin G, Thau K, Willeit M . Lithium in drinking water and suicide mortality. Br J Psychiatry. 2011; 198(5):346-50. DOI: 10.1192/bjp.bp.110.091041. View

19.

Sofola-Adesakin O, Castillo-Quan J, Rallis C, Tain L, Bjedov I, Rogers I . Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease. Front Aging Neurosci. 2014; 6:190. PMC: 4115666. DOI: 10.3389/fnagi.2014.00190. View

20.

Nussbaum R, Ellis C . Alzheimer's disease and Parkinson's disease. N Engl J Med. 2003; 348(14):1356-64. DOI: 10.1056/NEJM2003ra020003. View