Functional Abnormalities and Thyroid Nodules in Patients with End-stage Renal Disease

Overview

Journal In Vivo

Specialty Oncology

Date 2017 Nov 6

PMID 29102947

Citations 6

Authors

Vania Cuna

Viola Menghi

Giorgia Comai

Maria Cappuccilli

Giuseppe Cianciolo

Concettina Raimondi

Francesco Grammatico

Gabriele Donati

Olga Baraldi

Irene Capelli

Gaetano La Manna

Affiliations

Soon will be listed here.

Abstract

Background/aim: Clinical and subclinical hypothyroidism is more common in patients with end-stage renal disease (ESRD) than in the general population. Patients with ESRD with hypothyroidism are more susceptible to cardiovascular disease, with an increased risk of mortality than those with normal thyroid function. Moreover, these patients have higher incidence of benign and malignant nodules.

Patients And Methods: This was a retrospective study on 2,147 patients with ESRD on the renal transplant waiting list between 2000 and 2015 aimed at identifying the presence of hypothyroidism and associated variables.

Results: Hypothyroidism was detected in 437/2,147 (20.3%) patients, 289 of them having the subclinical form. Cardiovascular disease and older age were significantly associated with hypothyroidism, and autosomal polycystic kidney disease was correlated to goiter (p<0.001).

Conclusion: Thyroid abnormalities, particularly hypothyroidism with nodules, should be investigated in patients with ESRD on a waiting list for renal transplant to control cardiovascular complications and cancer risk.

Citing Articles

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Benign nodules of the thyroid gland and 25-hydroxy-vitamin D levels in euthyroid patients.

Bolat H, Erdogan A Ann Saudi Med. 2022; 42(2):83-88.

PMID: 35380060 PMC: 8982002. DOI: 10.5144/0256-4947.2022.83.

Incidence of thyroid nodules in early stage autosomal polycystic kidney disease.

Zalewska E, Kaniuka-Jakubowska S, Wisniewski P, Jankowska M, Sworczak K, Debska-Slizien A BMC Nephrol. 2022; 23(1):85.

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Prevalence of Hypothyroidism among Dialysis Patients in Palestine: A Cross-Sectional Study.

Nazzal Z, Khazneh E, Rabi R, Hammoudeh A, Ghanem A, Zaidan M Int J Nephrol. 2020; 2020:2683123.

PMID: 32455016 PMC: 7243013. DOI: 10.1155/2020/2683123.

Thyroid Pathology in End-Stage Renal Disease Patients on Hemodialysis.

Cotoi L, Borcan F, Sporea I, Amzar D, Schiller O, Schiller A Diagnostics (Basel). 2020; 10(4).

PMID: 32340182 PMC: 7236006. DOI: 10.3390/diagnostics10040245.

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