Anaphylactic Symptoms Due to Chlorhexidine Gluconate

Overview

Journal Arch Dermatol

Specialty Dermatology

Date 1989 Jan 1

PMID 2910207

Citations 22

Authors

M Okano

M Nomura

S Hata

N Okada

K Sato

Y Kitano

M Tashiro

Y Yoshimoto

R Hama

T Aoki

Affiliations

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Abstract

Six patients who developed urticaria, dyspnea, and anaphylactic shock due to topical application of chlorhexidine gluconate solution are described. Chlorhexidine gluconate was confirmed as the causative agent of type I hypersensitivity by intradermal, scratch, and epicutaneous tests. To prevent life-threatening adverse reactions, it seems important to use chlorhexidine gluconate on wound surfaces at a concentration of 0.05%, as recommended by the manufacturer; chlorhexidine gluconate may not be suitable for application to mucous membranes.

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