Up-regulation of Long Non-coding RNA SNHG20 Promotes Ovarian Cancer Progression Via Wnt/β-catenin Signaling

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2017 Nov 5

PMID 29101241

Citations 24

Authors

Shanyang He

Yunhe Zhao

Xiaoping Wang

Yalan Deng

Zhiyong Wan

Shuzhong Yao

Hongwei Shen

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNA small nucleolar RNA host gene 20 (SNHG20) has been demonstrated to play crucial regulatory roles in many types of cancer. However, the biological function of long ncRNA (lncRNA) SNHG20 in ovarian cancer is still unclear. In the present study, we found that lncRNA SNHG20 was significantly increased in ovarian cancer. In addition, lncRNA SNHG20 knockdown suppressed the ovarian cancer progression, whereas overexpression of SNHG20 showed the opposite effects. Moreover, our results also revealed that lncRNA SNHG20 knockdown inhibited Wnt/β-catenin signaling activity by suppressing β-catenin expression and reversing the downstream target gene expression. Taken together, lncRNA SNHG20 plays an pivotal role in ovarian cancer progression by regulating Wnt/β-catenin signaling.

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