Synthesis, Characterization and in Vitro Antimicrobial Activity of Novel Fused Pyrazolo[3,4-c]pyridazine, Pyrazolo[3,4-d]pyrimidine, Thieno[3,2-c]pyrazole and Pyrazolo[3',4':4,5]thieno[2,3-d]pyrimidine Derivatives

Overview

Journal Chem Cent J

Publisher Biomed Central

Specialty Chemistry

Date 2017 Nov 4

PMID 29098473

Citations 10

Authors

Mohamed A M Abdel Reheim

Safaa M Baker

Affiliations

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Abstract

Background: Some novel substituted pyrazolone, pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidinone, thieno[3,2-c]pyrazole and pyrazolo[3',4':4,5]thieno[2,3-d]pyrimidine derivatives have been reported to possess various pharmacological activities like antimicrobial, antitumor and anti-inflammatory.

Results: A novel series of azoles and azines were designed and prepared via reaction of 1,3-diphenyl-1H-pyrazol-5(4H)-one with some electrophilic and nucleophilic reagents. The structures of target compounds were confirmed by elemental analyses and spectral data.

Conclusions: The antimicrobial activity of the target synthesized compounds were tested against various microorganisms such as Escherichia coli; Bacillus megaterium; Bacillus subtilis (Bacterial species), Fusarium proliferatum; Trichoderma harzianum; Aspergillus niger (fungal species) by the disc diffusion method. In general, the novel synthesized compounds showed a good antimicrobial activity against the previously mentioned microorganisms.

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