Incident Osteoarthritis and Osteoarthritis-related Joint Replacement Surgery in Patients with Ankylosing Spondylitis: A Secondary Cohort Analysis of a Nationwide, Population-based Health Claims Database

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2017 Nov 3

PMID 29095939

Citations 6

Authors

Ming-Chi Lu

Chien-Hsueh Tung

Chang-Chen Yang

Chun-Lung Wang

Kuang-Yung Huang

Malcolm Koo

Ning-Sheng Lai

Affiliations

Soon will be listed here.

Abstract

Background: Ankylosing spondylitis (AS) might be associated with an increased risk of secondary osteoarthritis. However, there is a lack of studies assessing its impact on osteoarthritis-related surgery. The aim of this secondary cohort study was to investigate the risk of symptomatic osteoarthritis and osteoarthritis-related surgery, including total hip replacement surgery (THRS) and total knee replacement surgery (TKRS) in patients with AS.

Methods: Using the Taiwan's National Health Insurance Research Database, we identified 3,462 patients with AS between 2000 and 2012. A comparison cohort was assembled consisting of five patients without AS, based on frequency matching for sex, 10-year age interval, and index year, for each patient with AS. Both groups were followed until diagnosis of the study outcomes or the end of the follow-up period.

Results: Male patients with AS exhibited a significantly higher incidence of osteoarthritis (adjusted incidence rate ratio [IRR] 1.43; P < 0.001), THRS (adjusted IRR 12.59; P < 0.001), and TKRS (adjusted IRR 1.89; P = 0.036). Moreover, analyses stratified by age group (20-39 years versus 40-80 years) indicated a high IRR (adjusted IRR 27.66; P <0.001) for THRS among younger patients with AS.

Conclusions: Male patients with AS had a significant higher risk of developing osteoarthritis, and receiving THRS and TKRS. Young patients with AS also showed a significant higher risk of receiving THRS.

Citing Articles

Causality between Ankylosing Spondylitis and osteoarthritis in European ancestry: a bidirectional Mendelian randomization study.

Lu Y, Lu D, Zhang H, Li H, Yu B, Zhang Y Front Immunol. 2024; 15:1297454.

PMID: 38380324 PMC: 10876785. DOI: 10.3389/fimmu.2024.1297454.

Increased Risk of Common Orthopedic Surgeries for Patients with Rheumatic Diseases in Taiwan.

Hsieh M, Koo M, Hsu C, Lu M Medicina (Kaunas). 2022; 58(11).

PMID: 36422167 PMC: 9699140. DOI: 10.3390/medicina58111629.

Increased Incidence of Total Knee Replacement Surgery in Patients With Psoriasis: A Secondary Cohort Analysis of a Nationwide, Population-Based Health Claims Database.

Lu M, Fan K, Hsu C, Koo M, Lai N Front Med (Lausanne). 2021; 8:666802.

PMID: 34046419 PMC: 8144332. DOI: 10.3389/fmed.2021.666802.

Development and formulation of the classification criteria for osteoarthritis.

Huang C, Zhang Z, Chen Y, Zhang Y, Xing D, Zhao L Ann Transl Med. 2020; 8(17):1068.

PMID: 33145287 PMC: 7575945. DOI: 10.21037/atm-20-4673.

[Long version on the S3 guidelines for axial spondyloarthritis including Bechterew's disease and early forms, Update 2019 : Evidence-based guidelines of the German Society for Rheumatology (DGRh) and participating medical scientific specialist...].

Kiltz U, Braun J, Becker A, Chenot J, Dreimann M, Hammel L Z Rheumatol. 2019; 78(Suppl 1):3-64.

PMID: 31784900 DOI: 10.1007/s00393-019-0670-3.

References

Berenbaum F . Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthritis Cartilage. 2012; 21(1):16-21. DOI: 10.1016/j.joca.2012.11.012. View

Loeser R . Aging processes and the development of osteoarthritis. Curr Opin Rheumatol. 2012; 25(1):108-13. PMC: 3713615. DOI: 10.1097/BOR.0b013e32835a9428. View

Haut E, Pronovost P . Surveillance bias in outcomes reporting. JAMA. 2011; 305(23):2462-3. DOI: 10.1001/jama.2011.822. View

Lee W, Reveille J, Davis Jr J, Learch T, Ward M, Weisman M . Are there gender differences in severity of ankylosing spondylitis? Results from the PSOAS cohort. Ann Rheum Dis. 2006; 66(5):633-8. PMC: 1954622. DOI: 10.1136/ard.2006.060293. View

Das S, Farooqi A . Osteoarthritis. Best Pract Res Clin Rheumatol. 2008; 22(4):657-75. DOI: 10.1016/j.berh.2008.07.002. View

van der Linden S, VALKENBURG H, Cats A . Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 1984; 27(4):361-8. DOI: 10.1002/art.1780270401. View

Webers C, Essers I, Ramiro S, Stolwijk C, Landewe R, van der Heijde D . Gender-attributable differences in outcome of ankylosing spondylitis: long-term results from the Outcome in Ankylosing Spondylitis International Study. Rheumatology (Oxford). 2015; 55(3):419-28. DOI: 10.1093/rheumatology/kev340. View

Gracey E, Yao Y, Green B, Qaiyum Z, Baglaenko Y, Lin A . Sexual Dimorphism in the Th17 Signature of Ankylosing Spondylitis. Arthritis Rheumatol. 2015; 68(3):679-89. DOI: 10.1002/art.39464. View

Rudwaleit M, Landewe R, van der Heijde D, Listing J, Brandt J, Braun J . The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part I): classification of paper patients by expert opinion including uncertainty appraisal. Ann Rheum Dis. 2009; 68(6):770-6. DOI: 10.1136/ard.2009.108217. View

10.

Gorman J, Sack K, Davis Jr J . Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha. N Engl J Med. 2002; 346(18):1349-56. DOI: 10.1056/NEJMoa012664. View

11.

Ibn Yacoub Y, Amine B, Laatiris A, Hajjaj-Hassouni N . Gender and disease features in Moroccan patients with ankylosing spondylitis. Clin Rheumatol. 2011; 31(2):293-7. DOI: 10.1007/s10067-011-1819-x. View

12.

Kristensen L, Karlsson J, Englund M, Petersson I, Saxne T, Geborek P . Presence of peripheral arthritis and male sex predicting continuation of anti-tumor necrosis factor therapy in ankylosing spondylitis: an observational prospective cohort study from the South Swedish Arthritis Treatment Group Register. Arthritis Care Res (Hoboken). 2010; 62(10):1362-9. DOI: 10.1002/acr.20258. View

13.

Sokolove J, Lepus C . Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations. Ther Adv Musculoskelet Dis. 2013; 5(2):77-94. PMC: 3638313. DOI: 10.1177/1759720X12467868. View

14.

Yucesoy B, Charles L, Baker B, Burchfiel C . Occupational and genetic risk factors for osteoarthritis: a review. Work. 2013; 50(2):261-73. PMC: 4562436. DOI: 10.3233/WOR-131739. View

15.

Taurog J, Chhabra A, Colbert R . Ankylosing Spondylitis and Axial Spondyloarthritis. N Engl J Med. 2016; 374(26):2563-74. DOI: 10.1056/NEJMra1406182. View

16.

Wang X, Hunter D, Xu J, Ding C . Metabolic triggered inflammation in osteoarthritis. Osteoarthritis Cartilage. 2014; 23(1):22-30. DOI: 10.1016/j.joca.2014.10.002. View

17.

Thijssen E, van Caam A, van der Kraan P . Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis. Rheumatology (Oxford). 2014; 54(4):588-600. DOI: 10.1093/rheumatology/keu464. View

18.

Schafer V, Fleck M, Kellner H, Strunk J, Sattler H, Schmidt W . Evaluation of the novel ultrasound score for large joints in psoriatic arthritis and ankylosing spondylitis: six month experience in daily clinical practice. BMC Musculoskelet Disord. 2013; 14:358. PMC: 3878335. DOI: 10.1186/1471-2474-14-358. View

19.

Dakwar E, Reddy J, Vale F, Uribe J . A review of the pathogenesis of ankylosing spondylitis. Neurosurg Focus. 2008; 24(1):E2. DOI: 10.3171/FOC/2008/24/1/E2. View

20.

Sochart D, Porter M . Long-term results of total hip replacement in young patients who had ankylosing spondylitis. Eighteen to thirty-year results with survivorship analysis. J Bone Joint Surg Am. 1997; 79(8):1181-9. DOI: 10.2106/00004623-199708000-00010. View