Progressive and Prognosis Value of Notch Receptors and Ligands in Hepatocellular Carcinoma: A Systematic Review and Meta-analysis

Overview

Journal Sci Rep

Specialty Science

Date 2017 Nov 3

PMID 29093570

Citations 22

Authors

Yingshi Zhang

Dandan Li

Fan Feng

Li An

Fuhai Hui

Dasheng Dang

Qingchun Zhao

Affiliations

Soon will be listed here.

Abstract

Hepatocellular carcinoma (HCC) is not sensitive to radiotherapy and chemotherapy and experiences postoperative relapse extremely easy, which is the major cause of the high mortality rate. The Notch signaling pathway is expected to become a new target for the biological treatment of HCC. We searched databases for studies that evaluated the expression of Notch receptors and/or ligands in human HCC tissue. The search yielded 15 studies that enrolled 1643 patients. Compared with non-HCC tissues, Notch 1 was associated with a higher expression level (odds risk 1.59, 95% confidence interval 0.34 to 7.45), as well as Notch 3 (2.63, 0.69 to 10.02), Notch 4 (1.33, 0.74 to 2.38) and Jagged 1 (1.47, 0.23 to 9.53); however, Notch 2 showed the opposite result (0.60, 0.30 to 1.20). Larger tumor size (>5 cm), metastasis positive, and micro vascular invasion positive were features that were associated with over-expression in Notch 1 according to the clinicopathological features. The expression levels of Notch 1, 3, 4 and Jagged 1 were associated with higher expression in HCC tissues, while Notch 2 had the opposite result. This study is registered with PROSPERO (CRD42017055782).

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References

Santos S, Sheldon H, Pereira J, Paluch C, Bridges E, El-Cheikh M . Galectin-3 acts as an angiogenic switch to induce tumor angiogenesis via Jagged-1/Notch activation. Oncotarget. 2017; 8(30):49484-49501. PMC: 5564783. DOI: 10.18632/oncotarget.17718. View

Higgins J, Thompson S . Quantifying heterogeneity in a meta-analysis. Stat Med. 2002; 21(11):1539-58. DOI: 10.1002/sim.1186. View

Guyatt G, Oxman A, Vist G, Kunz R, Falck-Ytter Y, Alonso-Coello P . GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008; 336(7650):924-6. PMC: 2335261. DOI: 10.1136/bmj.39489.470347.AD. View

Hu L, Xue F, Shao M, Deng A, Wei G . Aberrant expression of Notch3 predicts poor survival for hepatocellular carcinomas. Biosci Trends. 2013; 7(3):152-6. View

Yuan X, Zhang M, Wu H, Xu H, Han N, Chu Q . Expression of Notch1 Correlates with Breast Cancer Progression and Prognosis. PLoS One. 2015; 10(6):e0131689. PMC: 4488260. DOI: 10.1371/journal.pone.0131689. View

Weijzen S, Rizzo P, Braid M, Vaishnav R, Jonkheer S, Zlobin A . Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med. 2002; 8(9):979-86. DOI: 10.1038/nm754. View

Liu Z, Dai X, Wang T, Zhang C, Zhang W, Zhang W . Hepatitis B virus PreS1 facilitates hepatocellular carcinoma development by promoting appearance and self-renewal of liver cancer stem cells. Cancer Lett. 2017; 400:149-160. DOI: 10.1016/j.canlet.2017.04.017. View

Zhu B, Sun L, Luo W, Li M, Coy D, Yu L . Activated Notch signaling augments cell growth in hepatocellular carcinoma via up-regulating the nuclear receptor NR4A2. Oncotarget. 2017; 8(14):23289-23302. PMC: 5410304. DOI: 10.18632/oncotarget.15576. View

Wang F, Fan J, Zhang Z, Gao B, Wang H . The global burden of liver disease: the major impact of China. Hepatology. 2014; 60(6):2099-108. PMC: 4867229. DOI: 10.1002/hep.27406. View

10.

Li L, Che L, Tharp K, Park H, Pilo M, Cao D . Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans. Hepatology. 2016; 63(6):1900-13. PMC: 4874885. DOI: 10.1002/hep.28508. View

11.

Zhu J, Jiang L, Jiang J, Yang X, Li X, Zeng J . Hepatocyte nuclear factor-1beta enhances the stemness of hepatocellular carcinoma cells through activation of the Notch pathway. Sci Rep. 2017; 7(1):4793. PMC: 5500528. DOI: 10.1038/s41598-017-04116-7. View

12.

Wang M, Xue L, Cao Q, Lin Y, Ding Y, Yang P . Expression of Notch1, Jagged1 and beta-catenin and their clinicopathological significance in hepatocellular carcinoma. Neoplasma. 2009; 56(6):533-41. DOI: 10.4149/neo_2009_06_533. View

13.

Shimizu K, Chiba S, Saito T, Kumano K, Hamada Y, Hirai H . Functional diversity among Notch1, Notch2, and Notch3 receptors. Biochem Biophys Res Commun. 2002; 291(4):775-9. DOI: 10.1006/bbrc.2002.6528. View

14.

Yuan X, Wu H, Xu H, Han N, Chu Q, Yu S . Meta-analysis reveals the correlation of Notch signaling with non-small cell lung cancer progression and prognosis. Sci Rep. 2015; 5:10338. PMC: 4440529. DOI: 10.1038/srep10338. View

15.

Jia H, Yang Q, Wang T, Cao Y, Jiang Q, Ma H . Rhamnetin induces sensitization of hepatocellular carcinoma cells to a small molecular kinase inhibitor or chemotherapeutic agents. Biochim Biophys Acta. 2016; 1860(7):1417-30. DOI: 10.1016/j.bbagen.2016.04.007. View

16.

Zhou L, Zhang N, Song W, You N, Li Q, Sun W . The significance of Notch1 compared with Notch3 in high metastasis and poor overall survival in hepatocellular carcinoma. PLoS One. 2013; 8(2):e57382. PMC: 3585338. DOI: 10.1371/journal.pone.0057382. View

17.

Qiu J, Peng B, Tang Y, Qian Y, Guo P, Li M . CpG Methylation Signature Predicts Recurrence in Early-Stage Hepatocellular Carcinoma: Results From a Multicenter Study. J Clin Oncol. 2017; 35(7):734-742. DOI: 10.1200/JCO.2016.68.2153. View

18.

Milner L, Bigas A . Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation. Blood. 1999; 93(8):2431-48. View

19.

Torre L, Bray F, Siegel R, Ferlay J, Lortet-Tieulent J, Jemal A . Global cancer statistics, 2012. CA Cancer J Clin. 2015; 65(2):87-108. DOI: 10.3322/caac.21262. View

20.

Jensen C, Jauho E, Santoni-Rugiu E, Holmskov U, Teisner B, Tygstrup N . Transit-amplifying ductular (oval) cells and their hepatocytic progeny are characterized by a novel and distinctive expression of delta-like protein/preadipocyte factor 1/fetal antigen 1. Am J Pathol. 2004; 164(4):1347-59. PMC: 1615354. DOI: 10.1016/S0002-9440(10)63221-X. View