Analysis of Colostrum IgA Against Bacteria Involved in Neonatal Infections

Overview

Journal Einstein (Sao Paulo)

Specialty General Medicine

Date 2017 Nov 2

PMID 29091144

Citations 3

Authors

Elizabeth Moreira Dias

Denise Bertulucci Rocha Rodrigues

Vinicius Rangel Geraldo-Martins

Ruchele Dias Nogueira

Affiliations

Soon will be listed here.

Abstract

Objective: To describe e compare the specificity of IgA antibodies against bacteria extract of Klebsiella pneumoniae , Staphylococcus aureus , Escherichia coli , and Salmonella enteritidis .

Methods: Colostrum samples were aseptically collected in the first 12 hours after C-section delivery. The specificity of IgA against bacteria extracts was analyzed by the Western blot.

Results: The findings showed proteins of high molecular weight frequently detectable in the samples. S. aureus was the most frequently found bacterium in the samples (p<0.05). Approximately 93.8, 56.3, 62.5 and 60.4% of samples presented IgA reactive to S. aureus , K. pneumoniae , S. enteritidis, and E. coli, respectively. Roughly 40% of samples showed no IgA reactive to K. pneumoniae, S. enteritidis and E. coli .

Conclusion: Clinical evidence of the importance of breastfeeding for the immune protection of neonates was consistent with the observed immunological findings, since most samples showed IgA reactive against the species tested. The application and development of immunotherapies during pregnancy, focused on frequently detected antigens, could be an important tool to enhance the presence of IgA in colostrum.

Citing Articles

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Infectious episodes during pregnancy, at particular mucosal sites, increase specific IgA1 or IgA2 subtype levels in human colostrum.

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