Effects of Strength Training and Raloxifene on Femoral Neck Metabolism and Microarchitecture of Aging Female Wistar Rats

Overview

Journal Sci Rep

Specialty Science

Date 2017 Nov 2

PMID 29089563

Citations 3

Authors

Camila Tami Stringhetta-Garcia

Samuel Rodrigues Lourenco Morais

Fernanda Fernandes

Melise Jacon Perez-Ueno

Ricardo de Paula Almeida

Mario Jefferson Quirino Louzada

Antonio Hernandes Chaves-Neto

Edilson Ervolino

Rita Cassia Menegati Dornelles

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to prevent female osteoporosis using strength training (ST), raloxifene (Ral) or a combination of ST plus Ral during the natural female aging process, specifically in the periestropause period. For a total of 120 days, aging female Wistar rats at 18-21 months of age performed ST on a ladder three times per week, and Ral was administered daily by gavage (1 mg/kg/day). Bone microarchitecture, areal bone mineral density, bone strength of the femoral neck, immunohistochemistry, osteoclast and osteoblast surface were assessed. We found that the treatments modulate the bone remodeling cycle in different ways. Both ST and Ral treatment resulted in improved bone microarchitecture in the femoral neck of rats in late periestropause. However, only ST improved cortical microarchitecture and bone strength in the femoral neck. Thus, we suggest that performing ST during the late period of periestropause is a valid intervention to prevent age-associated osteoporosis in females.

Citing Articles

The microarchitecture and chemical composition of the femur neck of senescent female rats after different physical training protocols.

Dos Santos Silva R, Peres-Ueno M, Nicola A, Santos L, Fernandes-Breitenbach F, Rubira R Geroscience. 2023; 46(2):1927-1946.

PMID: 37776397 PMC: 10828330. DOI: 10.1007/s11357-023-00948-6.

The Role of Oxidative Stress in Multiple Exercise-Regulated Bone Homeostasis.

Gao H, Zhao Y, Zhao L, Wang Z, Yan K, Gao B Aging Dis. 2023; 14(5):1555-1582.

PMID: 37196112 PMC: 10529750. DOI: 10.14336/AD.2023.0223.

Oxytocin and bone quality in the femoral neck of rats in periestropause.

Fernandes F, Stringhetta-Garcia C, Peres-Ueno M, Fernandes F, Nicola A, Castoldi R Sci Rep. 2020; 10(1):7937.

PMID: 32404873 PMC: 7220952. DOI: 10.1038/s41598-020-64683-0.

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