Prevention of Cancer at the Urothelial Enteric Anastomotic Site

Overview

Journal J Urol

Publisher Wolters Kluwer

Specialty Urology

Date 1989 Jan 1

PMID 2908946

Citations 4

Authors

C Shands 3rd

W S McDougal

E P Wright

Affiliations

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Abstract

An animal model of ureterosigmoidostomy was employed to elucidate the etiology of urinary intestinal anastomotic cancer. One hundred ninety-four rats were divided into five groups: vesicosigmoidostomy rats fed water without drug (controls); those fed ammonium chloride, or sodium bicarbonate, or ascorbic acid; and, finally, vesicosigmoid interposition rats. A significantly decreased incidence of cancer was evident only in the bowel interposition group (p less than 0.001). Ascorbic acid and altered urinary pH were not prophylactic. Possible mechanisms are discussed.

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