Effect of Propranolol on Ventricular Repolarization and Refractoriness: Role of Beta-blockade Versus Direct Membrane Effects

Overview

Journal Cardiovasc Drugs Ther

Specialties Cardiology & Vascular Diseases
Pharmacology

Date 1988 Mar 1

PMID 2908700

Citations 1

Authors

D E Euler

P J SCANLON

Affiliations

Soon will be listed here.

Abstract

The purpose of this study was to define the role of beta-adrenergic blockade and direct membrane effects in the ability of dl-propranolol to alter ventricular repolarization and refractoriness in the intact heart. The effective refractory period (ERP) and the local Q-T interval were measured at an epicardial site in the left ventricle in 14 open-chest dogs anesthetized with alpha-chloralose. Beta-adrenergic influences were eliminated in seven dogs (group 1) by stellate transection and nadolol (0.5 mg/kg IV), and enhanced in seven dogs (group 2) by stellate transection and stimulation of the left ansae subclavia. Each dog received an initial beta-blocking dose of propranolol (0.5 mg/kg) followed by a second, cumulative dose of 5.0 mg/kg. In group 1 dogs, there was no significant change in either the ERP or local Q-T interval in response to the first dose of propranolol. In group 2 dogs, left stellate stimulation significantly shortened the ERP (20 +/- 2 msec) and the local Q-T interval (17 +/- 4 msec). The first dose of propranolol prolonged these parameters to values not different from prestimulation control values. There was no change in the H-V interval, QRS complex duration, or diastolic threshold (DT) in either group after the initial propranolol dose. The second dose of propranolol significantly shortened the ERP (5 +/- 1 msec) and the local Q-T interval (11 +/- 2 msec) in both groups. This dose also significantly increased the DT, H-V interval, and QRS complex duration.(ABSTRACT TRUNCATED AT 250 WORDS)

Citing Articles

Cardiac effects of chronic oral beta-blockade: lack of agreement between heart rate and QT interval changes.

Extramiana F, Maison-Blanche P, Tavernier R, Jordaens L, Leenhardt A, Coumel P Ann Noninvasive Electrocardiol. 2002; 7(4):379-88.

PMID: 12431318 PMC: 7027610. DOI: 10.1111/j.1542-474x.2002.tb00189.x.

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