T2 Cell Development and Function

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2017 Oct 31

PMID 29082915

Citations 267

Authors

Jennifer A Walker

Andrew N J McKenzie

Affiliations

Soon will be listed here.

Abstract

T helper 2 (T2) cells orchestrate protective type 2 immune responses, such as those that target helminths and facilitate tissue repair, but also contribute to chronic inflammatory diseases, such as asthma and allergy. Here, we review recent insights into how diverse molecular signals from cellular sources, including dendritic cells, innate lymphoid cells and the epithelium, are integrated by T cells to guide the transcriptional and epigenetic changes necessary for T2 cell differentiation. Our improved understanding of these pathways has opened new avenues for therapeutically targeting T2 cells in asthma and allergy. The advent of comprehensive single-cell transcriptomics along with improvements in single-cell proteomics and the generation of novel in vivo cell fate mapping techniques promise to expand our understanding of T cell diversity and offer new insight into disease-related heterogeneity and plasticity of T cell responses.

Citing Articles

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