Immunoglobulin G Antibodies Against or in Cardiovascular Disease and Periodontitis

The aim was to elucidate whether levels of circulating antibodies to and correlate to loss of attachment, as a marker for periodontitis and cardiovascular disease (CVD). Sera were collected from 576 participants of the Danish Health Examination Survey (DANHES). Immunoglobulin G antibodies against lipopolysaccharide (LPS) and protein antigens from the a, b and c serotypes of and were quantified by titration in ELISA plates coated with a mixture of antigens prepared by disintegration of bacteria. Levels of antibodies against (OR = 1.48) and (1.31) associated with periodontitis, as determined by univariable logistic regression analysis. These antibody levels also associated with CVD (1.17 and 1.37), respectively, However, after adjusting for other risk factors, including age, smoking, gender, alcohol consumption, overweight, and level of education using multivariable logistic regression analysis, only increasing body mass index (BMI; 1.09), previous smoking (1.99), and increasing age (decades) (2.27) remained associated with CVD. Increased levels of antibodies against (1.34) remained associated with periodontitis after adjusting for other risk factors. CVD and periodontitis were associated with levels of IgG antibodies to or in univariable analyses, but only the association of antibody levels with periodontitis reached statistical significance after adjustment for common confounders. Age, in particular, influenced this relationship.