Chromothripsis is Linked to Alteration, Cell Cycle Impairment, and Dismal Outcome in Acute Myeloid Leukemia with Complex Karyotype

Overview

Journal Haematologica

Specialty Hematology

Date 2017 Oct 29

PMID 29079594

Citations 37

Authors

Frank G Rucker

Anna Dolnik

Tamara J Blatte

Veronica Teleanu

Aurelie Ernst

Felicitas Thol

Michael Heuser

Arnold Ganser

Hartmut Dohner

Konstanze Dohner

Lars Bullinger

Affiliations

Soon will be listed here.

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Chromothripsis is rare in IDH-mutant gliomas compared to IDH-wild-type glioblastomas whereas whole-genome duplication is equally frequent in both tumor types.

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Chromothripsis: an emerging crossroad from aberrant mitosis to therapeutic opportunities.

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References

Rucker F, Schlenk R, Bullinger L, Kayser S, Teleanu V, Kett H . TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome. Blood. 2011; 119(9):2114-21. DOI: 10.1182/blood-2011-08-375758. View

Subramanian A, Tamayo P, Mootha V, Mukherjee S, Ebert B, Gillette M . Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005; 102(43):15545-50. PMC: 1239896. DOI: 10.1073/pnas.0506580102. View

Maciejowski J, Li Y, Bosco N, Campbell P, de Lange T . Chromothripsis and Kataegis Induced by Telomere Crisis. Cell. 2015; 163(7):1641-54. PMC: 4687025. DOI: 10.1016/j.cell.2015.11.054. View

Korbel J, Campbell P . Criteria for inference of chromothripsis in cancer genomes. Cell. 2013; 152(6):1226-36. DOI: 10.1016/j.cell.2013.02.023. View

Rode A, Maass K, Willmund K, Lichter P, Ernst A . Chromothripsis in cancer cells: An update. Int J Cancer. 2015; 138(10):2322-33. DOI: 10.1002/ijc.29888. View

Yang X, Wang P, Liu J, Zhang H, Xi W, Jia X . Coordinated regulation of the immunoproteasome subunits by PML/RARα and PU.1 in acute promyelocytic leukemia. Oncogene. 2013; 33(21):2700-8. DOI: 10.1038/onc.2013.224. View

Stephens P, Greenman C, Fu B, Yang F, Bignell G, Mudie L . Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell. 2011; 144(1):27-40. PMC: 3065307. DOI: 10.1016/j.cell.2010.11.055. View

Rausch T, Jones D, Zapatka M, Stutz A, Zichner T, Weischenfeldt J . Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. Cell. 2012; 148(1-2):59-71. PMC: 3332216. DOI: 10.1016/j.cell.2011.12.013. View

Colla S, Ong D, Ogoti Y, Marchesini M, Mistry N, Clise-Dwyer K . Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome. Cancer Cell. 2015; 27(5):644-57. PMC: 4596059. DOI: 10.1016/j.ccell.2015.04.007. View

10.

Kim K, Baird K, Ahn J, Meltzer P, Lilly M, Levis M . Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival. Blood. 2004; 105(4):1759-67. DOI: 10.1182/blood-2004-05-2006. View

11.

Kloosterman W, Koster J, Molenaar J . Prevalence and clinical implications of chromothripsis in cancer genomes. Curr Opin Oncol. 2013; 26(1):64-72. DOI: 10.1097/CCO.0000000000000038. View

12.

Ji P, Agrawal S, Diederichs S, Baumer N, Becker A, Cauvet T . Cyclin A1, the alternative A-type cyclin, contributes to G1/S cell cycle progression in somatic cells. Oncogene. 2005; 24(16):2739-44. DOI: 10.1038/sj.onc.1208356. View

13.

Rucker F, Russ A, Cocciardi S, Kett H, Schlenk R, Botzenhardt U . Altered miRNA and gene expression in acute myeloid leukemia with complex karyotype identify networks of prognostic relevance. Leukemia. 2012; 27(2):353-61. DOI: 10.1038/leu.2012.208. View

14.

Ernst A, Jones D, Maass K, Rode A, Deeg K, Jebaraj B . Telomere dysfunction and chromothripsis. Int J Cancer. 2016; 138(12):2905-14. DOI: 10.1002/ijc.30033. View

15.

Dohner H, Estey E, Grimwade D, Amadori S, Appelbaum F, Buchner T . Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2016; 129(4):424-447. PMC: 5291965. DOI: 10.1182/blood-2016-08-733196. View