Nutrimiromics: Role of MicroRNAs and Nutrition in Modulating Inflammation and Chronic Diseases

Overview

Journal Nutrients

Date 2017 Oct 28

PMID 29077020

Citations 51

Authors

Bruna J Quintanilha

Bruna Z Reis

Graziela B Silva Duarte

Silvia M F Cozzolino

Marcelo M Rogero

Affiliations

Soon will be listed here.

Abstract

Nutrimiromics studies the influence of the diet on the modification of gene expression due to epigenetic processes related to microRNAs (miRNAs), which may affect the risk for the development of chronic diseases. miRNAs are a class of non-coding endogenous RNA molecules that are usually involved in post-transcriptional gene silencing by inducing mRNA degradation or translational repression by binding to a target messenger RNA. They can be controlled by environmental and dietary factors, particularly by isolated nutrients or bioactive compounds, indicating that diet manipulation may hold promise as a therapeutic approach in modulating the risk of chronic diseases. This review summarizes the evidence regarding the influence of nutrients and bioactive compounds on the expression of miRNAs related to inflammation and chronic disease in several models (cell culture, animal models, and human trials).

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