Protoparvovirus Cell Entry

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2017 Oct 27

PMID 29072600

Citations 22

Authors

Carlos Ros

Nooshin Bayat

Raphael Wolfisberg

Jose M Almendral

Affiliations

Soon will be listed here.

Abstract

The (PtPV) genus of the family of viruses includes important animal pathogens and reference molecular models for the entire family. Some virus members of the PtPV genus have arisen as promising tools to treat tumoral processes, as they exhibit marked oncotropism and oncolytic activities while being nonpathogenic for humans. The PtPVs invade and replicate within the nucleus making extensive use of the transport, transcription and replication machineries of the host cells. In order to reach the nucleus, PtPVs need to cross over several intracellular barriers and traffic through different cell compartments, which limit their infection efficiency. In this review we summarize molecular interactions, capsid structural transitions and hijacking of cellular processes, by which the PtPVs enter and deliver their single-stranded DNA genome into the host cell nucleus. Understanding mechanisms that govern the complex PtPV entry will be instrumental in developing approaches to boost their anticancer therapeutic potential and improving their safety profile.

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