Colorectal Cancer Incidence Trend and Projections in Tunisia (1994 - 2024)

Overview

Journal Asian Pac J Cancer Prev

Specialty Oncology

Date 2017 Oct 27

PMID 29072401

Citations 18

Authors

Houyem Khiari

Hizem Wided Ben Ayoub

Hajer Ben Khadhra

Mohamed Hsairi

Affiliations

Soon will be listed here.

Abstract

Objectives: The aim of this study was to describe trends of colorectal cancer incidence during the period 1994-2009 and to generate projections until 2024. Methods: The North-Tunisia Cancer Registry (NTCR) was the source of data for patients with CRC. This registry lists, since 1994, cases of malignant tumors in people living in North Tunisia, including the District of Tunis, the north east and the north west. Cases were classified using the International Classification of Diseases for Oncology. Data were analyzed using R software and Joinpoint one was employed to analyse trends. Projections were performed using the Age Period Cohort based on poisson regression. Results: During the period 1994 to 2009, 6,909 new cases of CRC were registered in Northern Tunisia. The age standardized incidence rate (ASR) increased significantly from 6.4/100,000 in 1994 to 12.4/100,000 in 2009. Trends in CRC incidence was significantly rising with an annual percentage change (APC) of + 3,9% [2.8% -5.1%]. Without effective interventions, the predicted CRC ASR would be 39.3/100,000 [CI 95%: 32,9/100,000 - 48,8/100,000] in 2024. Conclusion: The incidence of colorectal cancer is clearly increasing in Tunisia. Strengthening of screening and primary prevention measures is to be recommended.

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References

Lopez-Abente G, Ardanaz E, Torrella-Ramos A, Mateos A, Delgado-Sanz C, Chirlaque M . Changes in colorectal cancer incidence and mortality trends in Spain. Ann Oncol. 2010; 21 Suppl 3:iii76-82. DOI: 10.1093/annonc/mdq091. View

Brenner H, Stock C, Hoffmeister M . Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised controlled trials and observational studies. BMJ. 2014; 348:g2467. PMC: 3980789. DOI: 10.1136/bmj.g2467. View

Arafa M, Farhat K . Colorectal Cancer in the Arab World--Screening Practices and Future Prospects. Asian Pac J Cancer Prev. 2015; 16(17):7425-30. DOI: 10.7314/apjcp.2015.16.17.7425. View

Myer P, Mannalithara A, Singh G, Ladabaum U . Proximal and distal colorectal cancer resection rates in the United States since widespread screening by colonoscopy. Gastroenterology. 2012; 143(5):1227-1236. PMC: 4524880. DOI: 10.1053/j.gastro.2012.07.107. View

Mistry M, Parkin D, Ahmad A, Sasieni P . Cancer incidence in the United Kingdom: projections to the year 2030. Br J Cancer. 2011; 105(11):1795-803. PMC: 3242594. DOI: 10.1038/bjc.2011.430. View

Meguid R, Slidell M, Wolfgang C, Chang D, Ahuja N . Is there a difference in survival between right- versus left-sided colon cancers?. Ann Surg Oncol. 2008; 15(9):2388-94. PMC: 3072702. DOI: 10.1245/s10434-008-0015-y. View

Ismail S, Soubani M, Nimri J, Al-Zeer A . Cancer incidence in Jordan from 1996 to 2009--a comprehensive study. Asian Pac J Cancer Prev. 2013; 14(6):3527-34. DOI: 10.7314/apjcp.2013.14.6.3527. View

Imperiale T, Wagner D, Lin C, Larkin G, Rogge J, Ransohoff D . Risk of advanced proximal neoplasms in asymptomatic adults according to the distal colorectal findings. N Engl J Med. 2000; 343(3):169-74. DOI: 10.1056/NEJM200007203430302. View

Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh J, Comber H . Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer. 2013; 49(6):1374-403. DOI: 10.1016/j.ejca.2012.12.027. View

10.

Jarosz M, Sekula W, Rychlik E . Trends in dietary patterns, alcohol intake, tobacco smoking, and colorectal cancer in Polish population in 1960-2008. Biomed Res Int. 2013; 2013:183204. PMC: 3863469. DOI: 10.1155/2013/183204. View

11.

Ma Y, Yang Y, Wang F, Zhang P, Shi C, Zou Y . Obesity and risk of colorectal cancer: a systematic review of prospective studies. PLoS One. 2013; 8(1):e53916. PMC: 3547959. DOI: 10.1371/journal.pone.0053916. View

12.

West N, Boustiere C, Fischbach W, Parente F, Leicester R . Colorectal cancer screening in Europe: differences in approach; similar barriers to overcome. Int J Colorectal Dis. 2009; 24(7):731-40. DOI: 10.1007/s00384-009-0690-6. View

13.

Berghofer A, Pischon T, Reinhold T, Apovian C, Sharma A, Willich S . Obesity prevalence from a European perspective: a systematic review. BMC Public Health. 2008; 8:200. PMC: 2441615. DOI: 10.1186/1471-2458-8-200. View

14.

Kronborg O, Fenger C, Olsen J, Jorgensen O, Sondergaard O . Randomised study of screening for colorectal cancer with faecal-occult-blood test. Lancet. 1996; 348(9040):1467-71. DOI: 10.1016/S0140-6736(96)03430-7. View

15.

Johnson C, Wei C, Ensor J, Smolenski D, Amos C, Levin B . Meta-analyses of colorectal cancer risk factors. Cancer Causes Control. 2013; 24(6):1207-22. PMC: 4161278. DOI: 10.1007/s10552-013-0201-5. View

16.

Siegel R, DeSantis C, Jemal A . Colorectal cancer statistics, 2014. CA Cancer J Clin. 2014; 64(2):104-17. DOI: 10.3322/caac.21220. View

17.

Foreman L . Bowel cancer screening--a role for general practice. Aust Fam Physician. 2009; 38(4):200-3. View

18.

Center M, Jemal A, Ward E . International trends in colorectal cancer incidence rates. Cancer Epidemiol Biomarkers Prev. 2009; 18(6):1688-94. DOI: 10.1158/1055-9965.EPI-09-0090. View

19.

Yang L, Parkin D, Li L, Chen Y, Bray F . Estimation and projection of the national profile of cancer mortality in China: 1991-2005. Br J Cancer. 2004; 90(11):2157-66. PMC: 2409509. DOI: 10.1038/sj.bjc.6601813. View

20.

Cross A, Boca S, Freedman N, Caporaso N, Huang W, Sinha R . Metabolites of tobacco smoking and colorectal cancer risk. Carcinogenesis. 2014; 35(7):1516-22. PMC: 4076812. DOI: 10.1093/carcin/bgu071. View