Multidrug-resistant Infection with Ceftriaxone Resistance and Intermediate Resistance to Azithromycin, Denmark, 2017

Overview

Journal Euro Surveill

Specialty Infectious Diseases

Date 2017 Oct 26

PMID 29067905

Citations 45

Authors

David Terkelsen

Jacob Tolstrup

Camilla Hundahl Johnsen

Ole Lund

Helle Kiellberg Larsen

Peder Worning

Magnus Unemo

Henrik Westh

Affiliations

Soon will be listed here.

Abstract

We describe a multidrug-resistant infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.

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