Comparative Efficacy of Tulathromycin and Tildipirosin for the Treatment of Experimental Infection in Calves

Overview

Journal Vet Med Sci

Specialty Veterinary Medicine

Date 2017 Oct 26

PMID 29067192

Citations 6

Authors

David J Bartram

Hilde Moyaert

Bindu H Vanimisetti

Clifford P Ramage

David Reddick

Michael R Stegemann

Affiliations

Soon will be listed here.

Abstract

The objective of this negative controlled, blinded, randomised, parallel group study was to compare the efficacy of two injectable macrolide antimicrobials, tulathromycin and tildipirosin, administered by single subcutaneous injection at dose rates of 2.5 and 4.0 mg kg bodyweight, respectively, in the treatment of an experimentally induced infection in calves. A total of 238 negative calves were challenged on three consecutive days with by endobronchial deposition. Post-challenge, a total of 126 animals fulfilled the inclusion criteria and were randomly allocated to three treatment groups: tulathromycin, tildipirosin and saline. Clinical observations for signs of respiratory disease and injection site assessments were conducted daily for 14 days post-treatment. The animals were then killed, the lungs were examined for evidence of lesions, and samples collected for bacterial isolation. Calves treated with tulathromycin had a lower percentage of lung with lesions (=0.0079), lower mortality (=0.0477), fewer days with depressed demeanour (=0.0486) and higher body weight (=0.0112) than calves administered tildipirosin.

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