A Primary Map of Ten DNA Markers and Two Serological Markers for Human Chromosome 19

Overview

Journal Genomics

Specialty Genetics

Date 1988 Jul 1

PMID 2906044

Citations 17

Authors

Y Nakamura

M Lathrop

P OConnell

M Leppert

J M Lalouel

R White

Affiliations

Soon will be listed here.

Abstract

We have constructed a primary map of 10 DNA and 2 protein markers for chromosome 19. Three of the markers define loci with a variable number of tandem repeats (VNTRs); 3 define genes--insulin receptor, low-density lipoprotein (LDL) receptor, and apolipoprotein CII; and 2 are classical markers for blood group antigens (Lewis and Secretor). The estimated genetic distance covered by the map is 137 cM in males and 189 cM in females. In some regions of the chromosome we found significant differences in recombination frequencies according to sex. This set of markers will be efficient for linkage studies in families segregating genetic defects and will provide anchor points for a high-resolution map of chromosome 19.

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The 1.5-Mb region spanning the myotonic dystrophy locus shows uniform recombination frequency.

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