Serotonin Analogues As Inhibitors of Breast Cancer Cell Growth

Overview

Journal ACS Med Chem Lett

Publisher American Chemical Society

Specialty Chemistry

Date 2017 Oct 24

PMID 29057053

Citations 11

Authors

Jiney Jose

Clint D J Tavares

Nancy D Ebelt

Alessia Lodi

Ramakrishna Edupuganti

Xuemei Xie

Ashwini K Devkota

Tamer S Kaoud

Carla L Van Den Berg

Eric V Anslyn

Stefano Tiziani

Chandra Bartholomeusz

Kevin N Dalby

Affiliations

Soon will be listed here.

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) is a critical local regulator of epithelial homeostasis in the breast and exerts its actions through a number of receptors. Dysregulation of serotonin signaling is reported to contribute to breast cancer pathophysiology by enhancing cell proliferation and promoting resistance to apoptosis. Preliminary analyses indicated that the potent 5-HT1B/1D serotonin receptor agonist 5-nonyloxytryptamine (5-NT), a triptan-like molecule, induced cell death in breast cancer cell lines. Thus, we synthesized a series of novel alkyloxytryptamine analogues, several of which decreased the viability of various human cancer cell lines. Proteomic and metabolomic analyses showed that compounds and induced apoptosis and interfered with signaling pathways that regulate protein translation and survival, such as the Akt/mTOR pathway, in triple-negative breast cancer cells.

Citing Articles

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