Cross-talk Among Oxytocin and Arginine-vasopressin Receptors: Relevance for Basic and Clinical Studies of the Brain and Periphery

Overview

Journal Front Neuroendocrinol

Specialty Endocrinology

Date 2017 Oct 22

PMID 29054552

Citations 107

Authors

Zhimin Song

H Elliott Albers

Affiliations

Soon will be listed here.

Abstract

Oxytocin (OT) and arginine-vasopressin (AVP) act in the brain to regulate social cognition/social behavior and in the periphery to influence a variety of physiological processes. Although the chemical structures of OT and AVP as well as their receptors are quite similar, OT and AVP can have distinct or even opposing actions. Here, we review the increasing body of evidence that exogenously administered and endogenously released OT and AVP can activate each other's canonical receptors (i.e., cross-talk) and examine the possibility that receptor cross-talk following the synaptic and non-synaptic release of OT and AVP contributes to their distinct roles in the brain and periphery. Understanding the consequences of cross-talk between OT and AVP receptors will be important in identifying how these peptides control social cognition and behavior and for the development of drugs to treat a variety of psychiatric disorders.

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References

Rood B, de Vries G . Vasopressin innervation of the mouse (Mus musculus) brain and spinal cord. J Comp Neurol. 2011; 519(12):2434-74. PMC: 3939019. DOI: 10.1002/cne.22635. View

Caldwell H, Elliott Albers H . Effect of photoperiod on vasopressin-induced aggression in Syrian hamsters. Horm Behav. 2004; 46(4):444-9. DOI: 10.1016/j.yhbeh.2004.04.006. View

Johnson A, Barberis C, Albers H . Castration reduces vasopressin receptor binding in the hamster hypothalamus. Brain Res. 1995; 674(1):153-8. DOI: 10.1016/0006-8993(95)00010-n. View

Hawthorn J, Ang V, Jenkins J . Effects of lesions in the hypothalamic paraventricular, supraoptic and suprachiasmatic nuclei on vasopressin and oxytocin in rat brain and spinal cord. Brain Res. 1985; 346(1):51-7. DOI: 10.1016/0006-8993(85)91093-5. View

Carter C, Grippo A, Pournajafi-Nazarloo H, Ruscio M, Porges S . Oxytocin, vasopressin and sociality. Prog Brain Res. 2008; 170:331-6. DOI: 10.1016/S0079-6123(08)00427-5. View

de Vries G, Panzica G . Sexual differentiation of central vasopressin and vasotocin systems in vertebrates: different mechanisms, similar endpoints. Neuroscience. 2005; 138(3):947-55. PMC: 1457099. DOI: 10.1016/j.neuroscience.2005.07.050. View

Hasunuma I, Toyoda F, Okada R, Yamamoto K, Kadono Y, Kikuyama S . Roles of arginine vasotocin receptors in the brain and pituitary of submammalian vertebrates. Int Rev Cell Mol Biol. 2013; 304:191-225. DOI: 10.1016/B978-0-12-407696-9.00004-X. View

Song Z, Larkin T, Malley M, Elliott Albers H . Oxytocin (OT) and arginine-vasopressin (AVP) act on OT receptors and not AVP V1a receptors to enhance social recognition in adult Syrian hamsters (Mesocricetus auratus). Horm Behav. 2016; 81:20-7. DOI: 10.1016/j.yhbeh.2016.02.004. View

Vargas K, Sarmiento J, Ehrenfeld P, Anazco C, Villanueva C, Carmona P . Postnatal expression of V2 vasopressin receptor splice variants in the rat cerebellum. Differentiation. 2009; 77(4):377-85. PMC: 2846433. DOI: 10.1016/j.diff.2008.11.002. View

10.

Dumais K, Veenema A . Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior. Front Neuroendocrinol. 2015; 40:1-23. PMC: 4633405. DOI: 10.1016/j.yfrne.2015.04.003. View

11.

Ramos L, Hicks C, Kevin R, Caminer A, Narlawar R, Kassiou M . Acute prosocial effects of oxytocin and vasopressin when given alone or in combination with 3,4-methylenedioxymethamphetamine in rats: involvement of the V1A receptor. Neuropsychopharmacology. 2013; 38(11):2249-59. PMC: 3773675. DOI: 10.1038/npp.2013.125. View

12.

Knobloch H, Charlet A, Hoffmann L, Eliava M, Khrulev S, Cetin A . Evoked axonal oxytocin release in the central amygdala attenuates fear response. Neuron. 2012; 73(3):553-66. DOI: 10.1016/j.neuron.2011.11.030. View

13.

Johnson Z, Young L . Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience. Neurosci Biobehav Rev. 2017; 76(Pt A):87-98. PMC: 5407410. DOI: 10.1016/j.neubiorev.2017.01.034. View

14.

Dubois-Dauphin M, Pevet P, Tribollet E, Dreifuss J . Vasopressin in the brain of the golden hamster: the distribution of vasopressin binding sites and of immunoreactivity to the vasopressin-related glycopeptide. J Comp Neurol. 1990; 300(4):535-48. DOI: 10.1002/cne.903000408. View

15.

Leng G, Ludwig M . Neurotransmitters and peptides: whispered secrets and public announcements. J Physiol. 2008; 586(23):5625-32. PMC: 2655398. DOI: 10.1113/jphysiol.2008.159103. View

16.

Gabor C, Phan A, Clipperton-Allen A, Kavaliers M, Choleris E . Interplay of oxytocin, vasopressin, and sex hormones in the regulation of social recognition. Behav Neurosci. 2011; 126(1):97-109. DOI: 10.1037/a0026464. View

17.

Stoop R . Neuromodulation by oxytocin and vasopressin. Neuron. 2012; 76(1):142-59. DOI: 10.1016/j.neuron.2012.09.025. View

18.

Schorscher-Petcu A, Sotocinal S, Ciura S, Dupre A, Ritchie J, Sorge R . Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1A receptor in the mouse. J Neurosci. 2010; 30(24):8274-84. PMC: 2902996. DOI: 10.1523/JNEUROSCI.1594-10.2010. View

19.

Elliott Albers H . The regulation of social recognition, social communication and aggression: vasopressin in the social behavior neural network. Horm Behav. 2011; 61(3):283-92. DOI: 10.1016/j.yhbeh.2011.10.007. View

20.

Engelmann M, Wotjak C, Ebner K, Landgraf R . Behavioural impact of intraseptally released vasopressin and oxytocin in rats. Exp Physiol. 2000; 85 Spec No:125S-130S. DOI: 10.1111/j.1469-445x.2000.tb00015.x. View