Hypoxic Renal Injury in Newborns with Abdominal Compartment Syndrome (clinical and Experimental Study)

Overview

Journal Pediatr Res

Specialties Biology
Pediatrics

Date 2017 Oct 21

PMID 29053704

Citations 2

Authors

Dmitry Morozov

Olga Morozova

Dmitri Pervouchine

Lubov Severgina

Alexei Tsyplakov

Natalya Zakharova

Nikita Sushentsev

Larisa Maltseva

Ivan Budnik

Affiliations

Soon will be listed here.

Abstract

BackgroundSurgical treatment for gastroschisis and congenital diaphragmatic hernia (CDH) commonly leads to abdominal compartment syndrome (ACS) associated with hypoxic renal injury. We hypothesized that measurement of urinary and serum concentrations of vascular endothelial growth factor (VEGF), π-glutathione S-transferase (π-GST), and monocyte chemoattractant protein-1 (MCP-1) may serve for noninvasive detection of hypoxic renal injury in such patients.MethodsIntra-abdominal pressure (IAP), renal excretory function, and the biomarker levels were analyzed before, 4, and 10 days after surgery. Association between the biomarker levels and renal histology was investigated using an original model of ACS in newborn rats.ResultsFour days after surgery, IAP increased, renal excretory function decreased, and the levels of VEGF, π-GST, and MCP-1 increased, indicating renal injury. Ten days after surgery, IAP partially decreased, renal excretory function completely restored, but the biomarker levels remained elevated, suggesting the ongoing kidney injury. In the model of ACS, increase in the biomarker levels was associated with progressing kidney morphological alteration.ConclusionSurgical treatment for gastroschisis and CDH is associated with prolonged hypoxic kidney injury despite complete restoration of renal excretory function. Follow-up measurement of VEGF, π-GST, and MCP-1 levels may provide a better tool for noninvasive assessment of renal parenchyma in newborns with ACS.

Citing Articles

Acute kidney injury post-abdominal surgery in infants: implications for prevention and management.

Duong M, Kwak S, Bagrodia N, Basalely A Front Pediatr. 2023; 11:1162863.

PMID: 37152314 PMC: 10160454. DOI: 10.3389/fped.2023.1162863.

Effects of extensive mobilization and tension anastomosis in anorectal reconstruction (experimental study).

Morozov D, Morozova O, Severgina L, Mokrushina O, Marchuk T, Budnik I Pediatr Surg Int. 2022; 39(1):10.

PMID: 36441276 DOI: 10.1007/s00383-022-05306-9.

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