MiR-96-5p Prevents Hepatic Stellate Cell Activation by Inhibiting Autophagy Via ATG7

Overview

Journal J Mol Med (Berl)

Specialty General Medicine

Date 2017 Oct 21

PMID 29051972

Citations 21

Authors

Kangkang Yu

Ning Li

Qi Cheng

Jianming Zheng

Mengqi Zhu

Suxia Bao

Mingquan Chen

Guangfeng Shi

Affiliations

Soon will be listed here.

Abstract

Key Messages: • Altered miRNA expression profile is observed in fibrotic liver tissues. • miR-96-5p can inhibit HSC activation. • Autophagy of HSC is repressed by miR-96-5p during activation. • ATG7 is a direct target of miR-96-5p. • ATG7 can rescue miR-96-5p-mediated inhibition of autophagy and HSC activation.

Citing Articles

The IRE1α pathway in glomerular diseases: The unfolded protein response and beyond.

Navarro-Betancourt J, Cybulsky A Front Mol Med. 2024; 2:971247.

PMID: 39086958 PMC: 11285563. DOI: 10.3389/fmmed.2022.971247.

Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis.

Li S, Ren Q, Xie C, Cui Y, Xu L, Wang Y World J Gastroenterol. 2024; 30(15):2143-2154.

PMID: 38681990 PMC: 11045481. DOI: 10.3748/wjg.v30.i15.2143.

Bioinformatics and Experimental Study Revealed LINC00982/ miR-183-5p/ABCA8 Axis Suppresses LUAD Progression.

Ding D, Zhong J, Xing Y, Hu Y, Ge X, Yao W Curr Cancer Drug Targets. 2024; 24(6):654-667.

PMID: 38419344 DOI: 10.2174/0115680096266700231107071222.

Targeting mitophagy for neurological disorders treatment: advances in drugs and non-drug approaches.

Yang X, Zhang Y, Luo J, Zhu T, Ran Z, Mu B Naunyn Schmiedebergs Arch Pharmacol. 2023; 396(12):3503-3528.

PMID: 37535076 DOI: 10.1007/s00210-023-02636-w.

The Important Roles of Natural Killer Cells in Liver Fibrosis.

Yang M, Vanderwert E, Kimchi E, Staveley-OCarroll K, Li G Biomedicines. 2023; 11(5).

PMID: 37239062 PMC: 10216436. DOI: 10.3390/biomedicines11051391.

References

Hong Y, Liang H, Uzair-Ur-Rehman , Wang Y, Zhang W, Zhou Y . miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer. Sci Rep. 2016; 6:37421. PMC: 5114647. DOI: 10.1038/srep37421. View

Hsu C, Schwabe R . Autophagy and hepatic stellate cell activation - partners in crime?. J Hepatol. 2011; 55(6):1176-7. DOI: 10.1016/j.jhep.2011.08.001. View

Kinoshita C, Aoyama K, Matsumura N, Kikuchi-Utsumi K, Watabe M, Nakaki T . Rhythmic oscillations of the microRNA miR-96-5p play a neuroprotective role by indirectly regulating glutathione levels. Nat Commun. 2014; 5:3823. PMC: 4024755. DOI: 10.1038/ncomms4823. View

Mizushima N, Komatsu M . Autophagy: renovation of cells and tissues. Cell. 2011; 147(4):728-41. DOI: 10.1016/j.cell.2011.10.026. View

Thoen L, Guimaraes E, Dolle L, Mannaerts I, Najimi M, Sokal E . A role for autophagy during hepatic stellate cell activation. J Hepatol. 2011; 55(6):1353-60. DOI: 10.1016/j.jhep.2011.07.010. View

Friedman S . Evolving challenges in hepatic fibrosis. Nat Rev Gastroenterol Hepatol. 2010; 7(8):425-36. DOI: 10.1038/nrgastro.2010.97. View

Baik S, Lee J, Lee Y, Jang J, Kim C . ANT2 shRNA downregulates miR-19a and miR-96 through the PI3K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells. Exp Mol Med. 2016; 48:e222. PMC: 4892878. DOI: 10.1038/emm.2015.126. View

Ma Y, Yang H, Dong B, Zou H, Zhou Y, Kong X . Biphasic regulation of autophagy by miR-96 in prostate cancer cells under hypoxia. Oncotarget. 2014; 5(19):9169-82. PMC: 4253426. DOI: 10.18632/oncotarget.2396. View

Yu K, Shi G, Li N . The function of MicroRNA in hepatitis B virus-related liver diseases: from Dim to Bright. Ann Hepatol. 2015; 14(4):450-6. View

10.

Kuhn S, Johnson S, Furness D, Chen J, Ingham N, Hilton J . miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells. Proc Natl Acad Sci U S A. 2011; 108(6):2355-60. PMC: 3038748. DOI: 10.1073/pnas.1016646108. View

11.

Bataller R, Brenner D . Liver fibrosis. J Clin Invest. 2005; 115(2):209-18. PMC: 546435. DOI: 10.1172/JCI24282. View

12.

Xu J, Wang Y, Tan X, Jing H . MicroRNAs in autophagy and their emerging roles in crosstalk with apoptosis. Autophagy. 2012; 8(6):873-82. PMC: 3427253. DOI: 10.4161/auto.19629. View

13.

Bjorkoy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A . p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol. 2005; 171(4):603-14. PMC: 2171557. DOI: 10.1083/jcb.200507002. View

14.

Rautou P, Mansouri A, Lebrec D, Durand F, Valla D, Moreau R . Autophagy in liver diseases. J Hepatol. 2010; 53(6):1123-34. DOI: 10.1016/j.jhep.2010.07.006. View

15.

Yin C, Evason K, Asahina K, Stainier D . Hepatic stellate cells in liver development, regeneration, and cancer. J Clin Invest. 2013; 123(5):1902-10. PMC: 3635734. DOI: 10.1172/JCI66369. View

16.

Mallat A, Lodder J, Teixeira-Clerc F, Moreau R, Codogno P, Lotersztajn S . Autophagy: a multifaceted partner in liver fibrosis. Biomed Res Int. 2014; 2014:869390. PMC: 4164803. DOI: 10.1155/2014/869390. View

17.

Lodder J, Denaes T, Chobert M, Wan J, El-Benna J, Pawlotsky J . Macrophage autophagy protects against liver fibrosis in mice. Autophagy. 2015; 11(8):1280-92. PMC: 4590651. DOI: 10.1080/15548627.2015.1058473. View

18.

Szabo G, Bala S . MicroRNAs in liver disease. Nat Rev Gastroenterol Hepatol. 2013; 10(9):542-52. PMC: 4091636. DOI: 10.1038/nrgastro.2013.87. View

19.

Nho R, Im J, Ho Y, Hergert P . MicroRNA-96 inhibits FoxO3a function in IPF fibroblasts on type I collagen matrix. Am J Physiol Lung Cell Mol Physiol. 2014; 307(8):L632-42. PMC: 4200385. DOI: 10.1152/ajplung.00127.2014. View

20.

Lee U, Friedman S . Mechanisms of hepatic fibrogenesis. Best Pract Res Clin Gastroenterol. 2011; 25(2):195-206. PMC: 3079877. DOI: 10.1016/j.bpg.2011.02.005. View