MiR-200c Regulates Tumor Growth and Chemosensitivity to Cisplatin in Osteosarcoma by Targeting AKT2

Overview

Journal Sci Rep

Specialty Science

Date 2017 Oct 21

PMID 29051585

Citations 20

Authors

Yang Liu

Shu-Tao Zhu

Xiao Wang

Jun Deng

Wei-Hua Li

Peng Zhang

Bing-Shan Liu

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) expression aberration has been discovered in almost all human cancers, thus offering a group of potential diagnostic markers, prognostic factors and therapeutic targets in tumorigenesis. Now our data showed that miR-200c, which is downregulated in osteosarcoma tissues, drives chemosensitivity to cisplatin in osteosarcoma. We demonstrated that AKT2 is a direct target of miR-200c, Spearman's rank correlation analysis showed that the expression levels of AKT2 and miR-200c in 35 pairs of osteosarcoma specimens were inversely correlated. Moreover, miR-200c inhibited cell proliferation and cell migration. Taken together, for the first time, our results demonstrate that miR-200c plays a significant role in osteosarcoma tumor growth and chemosensitivity by regulating AKT2, which may provide a novel therapeutic strategy for treatment of osteosarcoma.

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